The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial
Objective To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile. Methods Women who had excess weight or obesity were recruited to a randomized, doubl...
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Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2017-01, Vol.25 (1), p.30-38 |
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creator | Gomes, Aline Corado de Sousa, Rávila Graziany Machado Botelho, Patrícia Borges Gomes, Tatyanne Letícia Nogueira Prada, Patrícia Oliveira Mota, João Felipe |
description | Objective
To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile.
Methods
Women who had excess weight or obesity were recruited to a randomized, double‐blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 1010 colony‐forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual‐energy X‐ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin‐6, interleukin‐10, tumor necrosis factor‐α, adiponectin, and the antioxidant enzymes activities were analyzed.
Results
In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (−3.40% vs. −5.48%, P = 0.03), waist‐height ratio (−3.27% vs. −5.00%, P = 0.02), conicity index (−2.43% vs. −4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. −18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (−16.67% vs. 15.62%, P |
doi_str_mv | 10.1002/oby.21671 |
format | Article |
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To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile.
Methods
Women who had excess weight or obesity were recruited to a randomized, double‐blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 1010 colony‐forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual‐energy X‐ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin‐6, interleukin‐10, tumor necrosis factor‐α, adiponectin, and the antioxidant enzymes activities were analyzed.
Results
In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (−3.40% vs. −5.48%, P = 0.03), waist‐height ratio (−3.27% vs. −5.00%, P = 0.02), conicity index (−2.43% vs. −4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. −18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (−16.67% vs. 15.62%, P < 0.01).
Conclusions
Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21671</identifier><identifier>PMID: 28008750</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adiposity - drug effects ; Adult ; Antioxidants ; Antioxidants - administration & dosage ; Bacteria ; Body Mass Index ; Diet, Reducing - methods ; Disease ; Double-Blind Method ; Enzymes ; Fatty acids ; Female ; Food ; Hormone replacement therapy ; Humans ; Metabolism ; Nutrition research ; Obesity ; Obesity, Abdominal - drug therapy ; Obesity, Abdominal - prevention & control ; Probiotics ; Probiotics - administration & dosage ; Rodents ; Studies ; Womens health</subject><ispartof>Obesity (Silver Spring, Md.), 2017-01, Vol.25 (1), p.30-38</ispartof><rights>2016 The Obesity Society</rights><rights>2016 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Jan 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-6be27ecc3c25fdb80abaabf938c1a8fab06a28a11270baec024cb36f0fe091b03</citedby><cites>FETCH-LOGICAL-c3881-6be27ecc3c25fdb80abaabf938c1a8fab06a28a11270baec024cb36f0fe091b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.21671$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.21671$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28008750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomes, Aline Corado</creatorcontrib><creatorcontrib>de Sousa, Rávila Graziany Machado</creatorcontrib><creatorcontrib>Botelho, Patrícia Borges</creatorcontrib><creatorcontrib>Gomes, Tatyanne Letícia Nogueira</creatorcontrib><creatorcontrib>Prada, Patrícia Oliveira</creatorcontrib><creatorcontrib>Mota, João Felipe</creatorcontrib><title>The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile.
Methods
Women who had excess weight or obesity were recruited to a randomized, double‐blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 1010 colony‐forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual‐energy X‐ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin‐6, interleukin‐10, tumor necrosis factor‐α, adiponectin, and the antioxidant enzymes activities were analyzed.
Results
In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (−3.40% vs. −5.48%, P = 0.03), waist‐height ratio (−3.27% vs. −5.00%, P = 0.02), conicity index (−2.43% vs. −4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. −18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (−16.67% vs. 15.62%, P < 0.01).
Conclusions
Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention.</description><subject>Adiposity - drug effects</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Bacteria</subject><subject>Body Mass Index</subject><subject>Diet, Reducing - methods</subject><subject>Disease</subject><subject>Double-Blind Method</subject><subject>Enzymes</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Food</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity, Abdominal - drug therapy</subject><subject>Obesity, Abdominal - prevention & control</subject><subject>Probiotics</subject><subject>Probiotics - administration & dosage</subject><subject>Rodents</subject><subject>Studies</subject><subject>Womens health</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctKxDAUBuAgiveFLyABNwrOeJJO24w7FW8guFBBV-XkhpG2GZsWHd34CD6jT2KcqgvBRThZfOeHw0_IBoMhA-B7Xk6HnGU5myPLbJzAIE_Gt_O_f8GWyEoIDwCjDFK2SJa4ABB5Csvk9freUNTatc7XWFJjrVFtoN5SpJPGS-dbp2jlnqmvKUrtK_flULuJD66dUqx1fHH92ek46VWLbRf26QHVvpOl-Xh7l6Wr9S5tIo3rL0bTtnFYrpEFi2Uw699zldycHF8fnQ0uLk_Pjw4uBioRgg0yaXhulEoUT62WAlAiSjtOhGIoLErIkAtkjOcg0SjgIyWTzII1MGYSklWy3efGex47E9qickGZssTa-C4UTKQ8F6MU0ki3_tAH3zXx4Jka8YT3aqdXqvEhNMYWk8ZV2EwLBsVXI0VspJg1Eu3md2InK6N_5U8FEez14MmVZvp_UnF5eNdHfgIBhJfP</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Gomes, Aline Corado</creator><creator>de Sousa, Rávila Graziany Machado</creator><creator>Botelho, Patrícia Borges</creator><creator>Gomes, Tatyanne Letícia Nogueira</creator><creator>Prada, Patrícia Oliveira</creator><creator>Mota, João Felipe</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial</title><author>Gomes, Aline Corado ; de Sousa, Rávila Graziany Machado ; Botelho, Patrícia Borges ; Gomes, Tatyanne Letícia Nogueira ; Prada, Patrícia Oliveira ; Mota, João Felipe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-6be27ecc3c25fdb80abaabf938c1a8fab06a28a11270baec024cb36f0fe091b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adiposity - drug effects</topic><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Bacteria</topic><topic>Body Mass Index</topic><topic>Diet, Reducing - methods</topic><topic>Disease</topic><topic>Double-Blind Method</topic><topic>Enzymes</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Food</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity, Abdominal - drug therapy</topic><topic>Obesity, Abdominal - prevention & control</topic><topic>Probiotics</topic><topic>Probiotics - administration & dosage</topic><topic>Rodents</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomes, Aline Corado</creatorcontrib><creatorcontrib>de Sousa, Rávila Graziany Machado</creatorcontrib><creatorcontrib>Botelho, Patrícia Borges</creatorcontrib><creatorcontrib>Gomes, Tatyanne Letícia Nogueira</creatorcontrib><creatorcontrib>Prada, Patrícia Oliveira</creatorcontrib><creatorcontrib>Mota, João Felipe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomes, Aline Corado</au><au>de Sousa, Rávila Graziany Machado</au><au>Botelho, Patrícia Borges</au><au>Gomes, Tatyanne Letícia Nogueira</au><au>Prada, Patrícia Oliveira</au><au>Mota, João Felipe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2017-01</date><risdate>2017</risdate><volume>25</volume><issue>1</issue><spage>30</spage><epage>38</epage><pages>30-38</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile.
Methods
Women who had excess weight or obesity were recruited to a randomized, double‐blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 1010 colony‐forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual‐energy X‐ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin‐6, interleukin‐10, tumor necrosis factor‐α, adiponectin, and the antioxidant enzymes activities were analyzed.
Results
In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (−3.40% vs. −5.48%, P = 0.03), waist‐height ratio (−3.27% vs. −5.00%, P = 0.02), conicity index (−2.43% vs. −4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. −18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (−16.67% vs. 15.62%, P < 0.01).
Conclusions
Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>28008750</pmid><doi>10.1002/oby.21671</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adiposity - drug effects Adult Antioxidants Antioxidants - administration & dosage Bacteria Body Mass Index Diet, Reducing - methods Disease Double-Blind Method Enzymes Fatty acids Female Food Hormone replacement therapy Humans Metabolism Nutrition research Obesity Obesity, Abdominal - drug therapy Obesity, Abdominal - prevention & control Probiotics Probiotics - administration & dosage Rodents Studies Womens health |
title | The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial |
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