The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double‐blind, randomized trial

Objective To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile. Methods Women who had excess weight or obesity were recruited to a randomized, double‐blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 1010 colony‐forming units/day) (n = 21) or placebo (n = 22) for 8 weeks. Both groups received a dietary prescription. Body composition was assessed by anthropometry and dual‐energy X‐ray absorptiometry. The lipid profile, lipid accumulation product, plasma fatty acids, lipopolysaccharide, interleukin‐6, interleukin‐10, tumor necrosis factor‐α, adiponectin, and the antioxidant enzymes activities were analyzed. Results In comparison with the dietary intervention group, the dietary intervention + probiotic mix group showed a greater reduction in the waist circumference (−3.40% vs. −5.48%, P = 0.03), waist‐height ratio (−3.27% vs. −5.00%, P = 0.02), conicity index (−2.43% vs. −4.09% P = 0.03), and plasma polyunsaturated fatty acids (5.65% vs. −18.63%, P = 0.04) and an increase in the activity of glutathione peroxidase (−16.67% vs. 15.62%, P