Previous malignancy is an independent predictor of follow‐up mortality after percutaneous treatment of mitral valve regurgitation by means of MitraClip

Summary Aims To investigate the prognostic burden of previously diagnosed and treated malignancies in candidates for percutaneous mitral valve repair (MVR) with MitraClip. Methods and Results A total of 165 patients underwent MVR and 19 (11.5%) had been previously treated for malignancy and considered healed with life expectancy over 1 year at time of percutaneous MVR. There was a significant trend for an increased overall risk profile (euroSCORE II 14.0±11.4 vs 10.0±6.7, P=.01) in patients with a previous diagnosis of neoplasia. Moreover, neoplastic patients had lower device success rates (78.9% vs 97.3%; P=.001), longer hospitalization (12.3±10.6 vs 7.5±4.9 days, P=.001), and higher 30‐day mortality (10.5% vs 2.7%, P=.09). Kaplan‐Meier overall estimated 1‐, 2‐, 3‐, and 4‐year survival of the overall cohort was 72%, 61%, 48%, and 44%, respectively. Estimated 1‐ and 2‐year survival were 44.4% and 22.2 % in patients with previous neoplasia and 75.3% and 65% in the remaining patients (P