Frustrated Lewis Acid/Brønsted Base Catalysts for Direct Enantioselective α‑Amination of Carbonyl Compounds
A method for enantioselective direct α-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Brønsted base complex is disclosed. Cooperative functioning of the Lewis acid and Brønsted base components gives rise to in situ enolate generation from monocarbonyl compounds. Subsequent reac...
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| Veröffentlicht in: | Journal of the American Chemical Society 2017-01, Vol.139 (1), p.95-98 |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A method for enantioselective direct α-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Brønsted base complex is disclosed. Cooperative functioning of the Lewis acid and Brønsted base components gives rise to in situ enolate generation from monocarbonyl compounds. Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers α-aminocarbonyl compounds in high enantiomeric purity. |
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| ISSN: | 0002-7863 1520-5126 |
| DOI: | 10.1021/jacs.6b11908 |