αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-01, Vol.53 (3), p.557-560
Hauptverfasser: Zhou, Yan, Chan, Chi-Fai, Kwong, Daniel W J, Law, Ga-Lai, Cobb, Steven, Wong, Wai-Kwok, Wong, Ka-Leung
Format: Artikel
Sprache:eng
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Zusammenfassung:We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.
ISSN:1364-548X
DOI:10.1039/c6cc09246b