Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5

Highlights • Knockdown of Sox10 or MCM5 in melanocytes leads to inhibition of melanocyte proliferation. • SOX10 directly activates MCM5 transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 promoter. • Defects in cell proliferation due to Sox10 reduction can be rescued part...

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Veröffentlicht in:	Journal of dermatological science 2017-03, Vol.85 (3), p.216-225
Hauptverfasser:	Su, Zhongyuan, Zheng, Xiaozi, Zhang, Xiaobo, Wang, Yipin, Zhu, Shanpu, Lu, Fan, Qu, Jia, Hou, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Lineage Cell Proliferation Cells, Cultured Dermatology DNA Replication - genetics Fluorescent Antibody Technique Gene Expression Regulation Gene Knockdown Techniques Gene regulation Humans Melanocytes - physiology Melanoma - genetics Melanoma - pathology Melanoma, Cutaneous Malignant Mice Mice, Inbred C57BL Neural crest Neural Crest - embryology Pigment cell Promoter Regions, Genetic RNA Interference RNA, Small Interfering - genetics Skin melanocytes Skin Neoplasms - genetics Skin Neoplasms - pathology SOXE Transcription Factors - genetics SOXE Transcription Factors - metabolism Transcription factor
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Zusammenfassung:	Highlights • Knockdown of Sox10 or MCM5 in melanocytes leads to inhibition of melanocyte proliferation. • SOX10 directly activates MCM5 transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 promoter. • Defects in cell proliferation due to Sox10 reduction can be rescued partially by overexpression of MCM5. • The SOX10-MCM5 axis plays an important role in control of melanocyte proliferation.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.12.002