Long-term effects of repeated maternal separation and ethanol intake on HPA axis responsiveness in adult rats

Highlights • Exposure to RMS plus cold stress increase voluntary ethanol intake in adolescent and adult rats. • The Western blot data revealed decrease protein levels of CRH and MR, while expression levels of GR increase. • Exposure to RMS and ethanol consumption reduce plasmatic levels of ACTH wher...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2017-02, Vol.1657, p.193-201
Hauptverfasser:	Odeon, María Mercedes, Yamauchi, Laura, Grosman, Mauricio, Acosta, Gabriela Beatriz
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Acute stress Adrenocorticotropic Hormone - blood Alcohol Drinking - metabolism Animals Animals, Newborn Central Nervous System Depressants - administration & dosage Cold Temperature Corticosterone Corticosterone - metabolism Corticotropin-Releasing Hormone - metabolism CRH Disease Models, Animal Ethanol - administration & dosage Ethanol consumption GC receptor HPA axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - growth & development Hypothalamo-Hypophyseal System - metabolism Male Maternal Deprivation MR receptor Neurology Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - growth & development Pituitary-Adrenal System - metabolism Random Allocation Rats, Wistar Receptors, Glucocorticoid - metabolism Receptors, Mineralocorticoid - metabolism Repeated maternal separation Resilience, Psychological Stress, Physiological - physiology Stress, Psychological - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Exposure to RMS plus cold stress increase voluntary ethanol intake in adolescent and adult rats. • The Western blot data revealed decrease protein levels of CRH and MR, while expression levels of GR increase. • Exposure to RMS and ethanol consumption reduce plasmatic levels of ACTH whereas enhance plasmatic levels of COR in HPA axis. • In response to new AS enhance plasmatic levels of ACTH and COR in HPA axis.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2016.11.034