Clinically proven drug targets differentially expressed in the prefrontal cortex of schizophrenia patients

Highlights • 1146 genes are differentially expressed in schizophrenia. • A strong pattern of differentially expressed immune response genes. • 23 genes are clinically proven drug targets as well as 20 antipsychotic agents. • 16 genes are associated with schizophrenia from the Psychiatric Genomics Co...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.259-265
Hauptverfasser:	Voisey, Joanne, Mehta, Divya, McLeay, Robert, Morris, Charles P, Wockner, Leesa F, Noble, Ernest P, Lawford, Bruce R, Young, Ross McD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Brain DNA Methylation Gene Expression Gene Expression Profiling Gene Expression Regulation Humans Immune response Methylation Prefrontal Cortex - metabolism Psychiatry RNA-Seq Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Signal Transduction - genetics Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights • 1146 genes are differentially expressed in schizophrenia. • A strong pattern of differentially expressed immune response genes. • 23 genes are clinically proven drug targets as well as 20 antipsychotic agents. • 16 genes are associated with schizophrenia from the Psychiatric Genomics Consortium.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.12.006