Genomic signatures of sex-biased demography: progress and prospects

Genomic signatures of sex-biased demography: progress and prospects

Sex-biased demographic events have played a crucial role in shaping human history. Many of these processes affect genetic variation and can therefore leave detectable signatures in the genome because autosomal, X-linked, Y-linked, and mitochondrial DNA inheritance differ between sexes. Here, we disc...

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Veröffentlicht in:Current opinion in genetics & development 2016-12, Vol.41, p.62-71
Hauptverfasser: Webster, Timothy H, Wilson Sayres, Melissa A
Format: Artikel
Sprache:eng
Schlagworte:
Demography
DNA, Mitochondrial - genetics
Female
Genetic Variation
Genetics, Population
Genome, Human - genetics
Genomics
Humans
Male
Medical Education
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Zusammenfassung:Sex-biased demographic events have played a crucial role in shaping human history. Many of these processes affect genetic variation and can therefore leave detectable signatures in the genome because autosomal, X-linked, Y-linked, and mitochondrial DNA inheritance differ between sexes. Here, we discuss how sex-biased processes shape patterns of genetic diversity across the genome, review recent genomic evidence for sex-biased demography in modern human populations, and suggest directions for future research.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2016.08.002