Dysfunctional organization of default mode network before memory impairments in type 2 diabetes

Highlights • T2DM exhibited reduced deactivation during episodic memory task with intact memory. • T2DM showed weakened task-related anterior-posterior connectivity within DMN. • T2DM showed decreased network global efficiency of DMN over a wide range of sparsity. • Altered deactivation was negative...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-12, Vol.74, p.141-148
Hauptverfasser:	Chen, Yaojing, MS, Liu, Zhen, MS, Wang, Ailin, BS, Zhang, Junying, MD, Zhang, Sisi, BS, Qi, Di, BS, Chen, Kewei, PhD, Zhang, Zhanjun, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer’s disease Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiopathology Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Connectome - methods Default mode network Diabetes Mellitus, Type 2 - complications Endocrinology & Metabolism Episodic memory Female Functional connectivity Humans Magnetic Resonance Imaging Male Memory Disorders - diagnostic imaging Memory Disorders - etiology Memory Disorders - physiopathology Memory, Episodic Middle Aged Psychiatry Topological organization Type 2 diabetes mellitus
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Zusammenfassung:	Highlights • T2DM exhibited reduced deactivation during episodic memory task with intact memory. • T2DM showed weakened task-related anterior-posterior connectivity within DMN. • T2DM showed decreased network global efficiency of DMN over a wide range of sparsity. • Altered deactivation was negatively related with altered connectivity in DMN.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.08.012