GLP-1 as a target for therapeutic intervention

Highlights • GLP-1 analogues are used in the management of type 2 diabetes and obesity. • They improve glycaemic control, promote weight loss and have a low risk of hypoglycaemia. • GLP-1 analogues are available for daily and weekly administration as injectables. • Gastrointestinal intolerance is th...

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Veröffentlicht in:	Current opinion in pharmacology 2016-12, Vol.31, p.44-49
Hauptverfasser:	Rajeev, Surya Panicker, Wilding, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - drug effects Body Weight - drug effects Diabetes Mellitus, Type 2 - drug therapy Drug Therapy, Combination Glucagon-Like Peptide 1 - metabolism Glucagon-Like Peptide-1 Receptor - agonists Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Insulin - metabolism Internal Medicine Liraglutide - administration & dosage Liraglutide - pharmacology Medical Education Obesity - drug therapy
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Beschreibung
Zusammenfassung:	Highlights • GLP-1 analogues are used in the management of type 2 diabetes and obesity. • They improve glycaemic control, promote weight loss and have a low risk of hypoglycaemia. • GLP-1 analogues are available for daily and weekly administration as injectables. • Gastrointestinal intolerance is the most common adverse effect.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2016.08.005