Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced Type 1 diabetes mellitus rats

Highlights • Troxerutin promotes learning and memory in STZ diabetic rats. • Troxerutin alleviates oxidative stress in diabetic rats. • Troxerutin relieves the altered hippocampal histology in diabetic rats. • The effects of troxerutin are similar in strength to those of alpha-lipoic acid.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2017-02, Vol.1657, p.355-360
Hauptverfasser:	Zhang, Songyun, Li, Hongyan, Zhang, Lihui, Li, Jie, Wang, Ruiying, Wang, Mian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-lipoic acid Animals Cognition Disorders - drug therapy Cognition Disorders - enzymology Cognition Disorders - etiology Cognition Disorders - pathology Cognitive deficits Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - psychology Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - enzymology Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - psychology Drug Evaluation, Preclinical Glutamate-Cysteine Ligase - metabolism Hippocampus Hippocampus - drug effects Hippocampus - enzymology Hippocampus - pathology Hydroxyethylrutoside - analogs & derivatives Hydroxyethylrutoside - pharmacology Hypoglycemic Agents - pharmacology Male Maze Learning - drug effects Maze Learning - physiology Neurology Nootropic Agents - pharmacology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Random Allocation Rats, Sprague-Dawley Thioctic Acid - pharmacology Troxerutin Type 1 diabetes mellitus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Troxerutin promotes learning and memory in STZ diabetic rats. • Troxerutin alleviates oxidative stress in diabetic rats. • Troxerutin relieves the altered hippocampal histology in diabetic rats. • The effects of troxerutin are similar in strength to those of alpha-lipoic acid.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2016.12.009