Impaired ApoB-Lipoprotein and Triglyceride Metabolism in Obese Adolescents with Polycystic Ovary Syndrome

Context:Adolescents with Polycystic Ovary Syndrome (PCOS) have atherogenic dyslipidemia and increased cardiovascular disease (CVD) risk, and this is exacerbated in obesity.Objective:To determine and compare fasting and non-fasting lipid and ApoB-lipoprotein metabolism in three groups of adolescent girls: i) healthy-weight controls, ii) obese without PCOS (obese-control) and iii) obese with PCOS (obese-PCOS).Design, setting and participants:Participants aged 12-17 years were recruited for this cross-sectional study from a pediatric weight management clinic and the local community in Alberta, Canada.Main Outcome Measures:Plasma lipids and ApoB-lipoproteins, including triglycerides (TG), ApoB100- and ApoB48-lipoproteins, were measured in the fasted and postprandial state following a high-fat meal.Results:Obese-control (n=12) and obese-PCOS (n=18) groups had two fold higher concentrations of fasting plasma TG, ApoB100- and ApoB48-lipoprotein remnants compared to healthy-weight controls (n=10) (ApoB48-lipoproteins;19.32 ± 2.10, 24.02 ± 4.28, 8.95±1.05 ug/ml, respectively, p