TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats
Highlights • A peptide derived from p35 TFP5 is neuroprotective in early-stage adult ischemic stroke. • TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage adult ischemic stroke. • TFP5 is given along with mild hypothermia, less neurological deficit after ischemi...
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| Veröffentlicht in: | Neuroscience 2017-02, Vol.343, p.337-345 |
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| container_end_page | 345 |
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| container_title | Neuroscience |
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| creator | Ji, Ya-Bin Zhuang, Pei-Pei Ji, Zhong Huang, Kai-Bin Gu, Yong Wu, Yong-Ming Pan, Su-Yue Hu, Ya-Fang |
| description | Highlights • A peptide derived from p35 TFP5 is neuroprotective in early-stage adult ischemic stroke. • TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage adult ischemic stroke. • TFP5 is given along with mild hypothermia, less neurological deficit after ischemic stroke tends to be achieved. |
| doi_str_mv | 10.1016/j.neuroscience.2016.12.009 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-2898e8a361c01a4c01385aa8d4bac811e0472c692231c6123fe423b3347486cf3</citedby><cites>FETCH-LOGICAL-c435t-2898e8a361c01a4c01385aa8d4bac811e0472c692231c6123fe423b3347486cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452216306996$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27998781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Ya-Bin</creatorcontrib><creatorcontrib>Zhuang, Pei-Pei</creatorcontrib><creatorcontrib>Ji, Zhong</creatorcontrib><creatorcontrib>Huang, Kai-Bin</creatorcontrib><creatorcontrib>Gu, Yong</creatorcontrib><creatorcontrib>Wu, Yong-Ming</creatorcontrib><creatorcontrib>Pan, Su-Yue</creatorcontrib><creatorcontrib>Hu, Ya-Fang</creatorcontrib><title>TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • A peptide derived from p35 TFP5 is neuroprotective in early-stage adult ischemic stroke. • TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage adult ischemic stroke. • TFP5 is given along with mild hypothermia, less neurological deficit after ischemic stroke tends to be achieved.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - therapy</subject><subject>CDK5/p25</subject><subject>CDK5/p35</subject><subject>Combined Modality Therapy</subject><subject>Cyclin-Dependent Kinase 5 - metabolism</subject><subject>Disease Models, Animal</subject><subject>hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Immunoglobulin G - metabolism</subject><subject>ischemia</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Neurology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Peptides - pharmacology</subject><subject>Random Allocation</subject><subject>Rats, Sprague-Dawley</subject><subject>Severity of Illness Index</subject><subject>stroke</subject><subject>Stroke - metabolism</subject><subject>Stroke - pathology</subject><subject>Stroke - therapy</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl-P1CAUxYnRuOPqVzDEJ1_a5V8p9cHE7LquySaauD4Tht7OMEvLCHSS-fZSZzTGJ3kAQs459_IDhN5QUlNC5dWunmCOIVkHk4WalbOaspqQ7glaUdXyqm2EeIpWhBNZiYaxC_QipR0poxH8ObpgbdepVtEVOjzcfm2wS9iGcW-iWXvAOeDR-R5vj_uQtxBHZ7CbsBv3MRzctMG_yvuwcdZ4HOZcvJAWCZjoj1XKZgMl025hdBanHMMj4DBg088-42hyeomeDcYneHVeL9H3248P13fV_ZdPn68_3FdW8CZXTHUKlOGSWkKNKBNXjTGqF2tjFaVARMus7Bjj1ErK-ACC8TXnohVK2oFforen3NL6jxlS1mPpC7w3E4Q5aaoaygmXTVek705SW9CmCIPeRzeaeNSU6IW73um_ueuFu6ZMF-7F_PpcZ16P0P-x_gZdBDcnAZTbHhxEfY7pXQSbdR_c_9V5_0-M9W5a3uERjpB2YY5T4ampTsWgvy0_YPkAVJZN10n-E_YGsOk</recordid><startdate>20170220</startdate><enddate>20170220</enddate><creator>Ji, Ya-Bin</creator><creator>Zhuang, Pei-Pei</creator><creator>Ji, Zhong</creator><creator>Huang, Kai-Bin</creator><creator>Gu, Yong</creator><creator>Wu, Yong-Ming</creator><creator>Pan, Su-Yue</creator><creator>Hu, Ya-Fang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170220</creationdate><title>TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats</title><author>Ji, Ya-Bin ; Zhuang, Pei-Pei ; Ji, Zhong ; Huang, Kai-Bin ; Gu, Yong ; Wu, Yong-Ming ; Pan, Su-Yue ; Hu, Ya-Fang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-2898e8a361c01a4c01385aa8d4bac811e0472c692231c6123fe423b3347486cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - therapy</topic><topic>CDK5/p25</topic><topic>CDK5/p35</topic><topic>Combined Modality Therapy</topic><topic>Cyclin-Dependent Kinase 5 - metabolism</topic><topic>Disease Models, Animal</topic><topic>hypothermia</topic><topic>Hypothermia, Induced</topic><topic>Immunoglobulin G - metabolism</topic><topic>ischemia</topic><topic>Male</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Neurology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Peptides - pharmacology</topic><topic>Random Allocation</topic><topic>Rats, Sprague-Dawley</topic><topic>Severity of Illness Index</topic><topic>stroke</topic><topic>Stroke - metabolism</topic><topic>Stroke - pathology</topic><topic>Stroke - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji, Ya-Bin</creatorcontrib><creatorcontrib>Zhuang, Pei-Pei</creatorcontrib><creatorcontrib>Ji, Zhong</creatorcontrib><creatorcontrib>Huang, Kai-Bin</creatorcontrib><creatorcontrib>Gu, Yong</creatorcontrib><creatorcontrib>Wu, Yong-Ming</creatorcontrib><creatorcontrib>Pan, Su-Yue</creatorcontrib><creatorcontrib>Hu, Ya-Fang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji, Ya-Bin</au><au>Zhuang, Pei-Pei</au><au>Ji, Zhong</au><au>Huang, Kai-Bin</au><au>Gu, Yong</au><au>Wu, Yong-Ming</au><au>Pan, Su-Yue</au><au>Hu, Ya-Fang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2017-02-20</date><risdate>2017</risdate><volume>343</volume><spage>337</spage><epage>345</epage><pages>337-345</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • A peptide derived from p35 TFP5 is neuroprotective in early-stage adult ischemic stroke. • TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage adult ischemic stroke. • TFP5 is given along with mild hypothermia, less neurological deficit after ischemic stroke tends to be achieved.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>27998781</pmid><doi>10.1016/j.neuroscience.2016.12.009</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acute Disease Animals Apoptosis - drug effects Apoptosis - physiology Brain - drug effects Brain - metabolism Brain - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - therapy CDK5/p25 CDK5/p35 Combined Modality Therapy Cyclin-Dependent Kinase 5 - metabolism Disease Models, Animal hypothermia Hypothermia, Induced Immunoglobulin G - metabolism ischemia Male Matrix Metalloproteinase 9 - blood Neurology Neuroprotective Agents - pharmacology Peptides - pharmacology Random Allocation Rats, Sprague-Dawley Severity of Illness Index stroke Stroke - metabolism Stroke - pathology Stroke - therapy |
| title | TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats |
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