TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats

Highlights • A peptide derived from p35 TFP5 is neuroprotective in early-stage adult ischemic stroke. • TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage adult ischemic stroke. • TFP5 is given along with mild hypothermia, less neurological deficit after ischemi...

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Veröffentlicht in:	Neuroscience 2017-02, Vol.343, p.337-345
Hauptverfasser:	Ji, Ya-Bin, Zhuang, Pei-Pei, Ji, Zhong, Huang, Kai-Bin, Gu, Yong, Wu, Yong-Ming, Pan, Su-Yue, Hu, Ya-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Apoptosis - drug effects Apoptosis - physiology Brain - drug effects Brain - metabolism Brain - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - therapy CDK5/p25 CDK5/p35 Combined Modality Therapy Cyclin-Dependent Kinase 5 - metabolism Disease Models, Animal hypothermia Hypothermia, Induced Immunoglobulin G - metabolism ischemia Male Matrix Metalloproteinase 9 - blood Neurology Neuroprotective Agents - pharmacology Peptides - pharmacology Random Allocation Rats, Sprague-Dawley Severity of Illness Index stroke Stroke - metabolism Stroke - pathology Stroke - therapy
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Zusammenfassung:	Highlights • A peptide derived from p35 TFP5 is neuroprotective in early-stage adult ischemic stroke. • TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage adult ischemic stroke. • TFP5 is given along with mild hypothermia, less neurological deficit after ischemic stroke tends to be achieved.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.12.009