Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta

Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta

Highlights • Magnesium Sulphate (MgSO4 ) is protective against LPS-stimulated inflammation in BeWo cytotrophoblast. • MgSO4 reduces pkynosis in LPS-stimulated cytotrophoblasts. • MgSO4 inhibits the expression of TNF-α.

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Veröffentlicht in:Pregnancy hypertension 2016-10, Vol.6 (4), p.356-360
Hauptverfasser: Williamson, Rachel D, McCarthy, Cathal, Kenny, Louise C, O’Keeffe, Gerard W
Format: Artikel
Sprache:eng
Schlagworte:
Anticonvulsants - pharmacology
Cardiovascular
Cell Death - drug effects
Cell Line, Tumor
Cell Survival - drug effects
Female
Gene Expression - drug effects
Humans
Lipopolysaccharides - pharmacology
Magnesium Sulfate - pharmacology
Obstetrics and Gynecology
Placenta
Pregnancy
RNA, Messenger - metabolism
Tumor Necrosis Factor-alpha - genetics
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Zusammenfassung:Highlights • Magnesium Sulphate (MgSO4 ) is protective against LPS-stimulated inflammation in BeWo cytotrophoblast. • MgSO4 reduces pkynosis in LPS-stimulated cytotrophoblasts. • MgSO4 inhibits the expression of TNF-α.
ISSN:2210-7789
2210-7797
DOI:10.1016/j.preghy.2016.08.237