The effects of hydroxychloroquine on endothelial dysfunction

Highlights • hydroxychloroquine reduces endothelin-1 release from endothelial cells • hydroxychloroquine improves endothelial cell capillary formation in vitro • hydroxychloroquine may be a useful adjuvant therapy for severe preeclampsia

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Bibliographische Detailangaben
Veröffentlicht in:	Pregnancy hypertension 2016-10, Vol.6 (4), p.259-262
Hauptverfasser:	Rahman, Rahana, Murthi, Padma, Singh, Harmeet, Gurusinghe, Seshini, Mockler, Joanne C, Lim, Rebecca, Wallace, Euan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - pharmacology Cardiovascular Endothelial dysfunction Endothelin-1 Endothelin-1 - biosynthesis Female Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hydroxychloroquine Hydroxychloroquine - pharmacology Neovascularization, Physiologic - drug effects Obstetrics and Gynecology Pre-Eclampsia - blood Preeclampsia Preeclamptic serum Pregnancy Primary Cell Culture Serum TNF-α Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • hydroxychloroquine reduces endothelin-1 release from endothelial cells • hydroxychloroquine improves endothelial cell capillary formation in vitro • hydroxychloroquine may be a useful adjuvant therapy for severe preeclampsia
ISSN:	2210-7789 2210-7797
DOI:	10.1016/j.preghy.2016.09.001