1.51 30-Year Follow-Up of Children and Adolescents With Disruptive Disorder: PSYCHIATRIC, GENERAL HEALTH, DEMOGRAPHIC, AND SOCIAL FUNCTIONING OUTCOMES
Objectives: Despite evidence in the literature for the risk of developing other psychiatric disorders in children and adolescents with disruptive disorders (DD), the long-term outcomes into adulthood need better clarification. The objective of this study is to evaluate several outcomes for children...
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| container_title | Journal of the American Academy of Child and Adolescent Psychiatry |
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| creator | Diaz, Alexandre Paim, PhD Warner, Virginia, DrPH Gameroff, Marc J., PhD Skipper, Jamie, MA Talati, Ardesheer, PhD Wickramaratne, Priya, PhD Weissman, Myrna M., PhD |
| description | Objectives: Despite evidence in the literature for the risk of developing other psychiatric disorders in children and adolescents with disruptive disorders (DD), the long-term outcomes into adulthood need better clarification. The objective of this study is to evaluate several outcomes for children and adolescents with DD diagnosis, including psychiatric disorders, suicide ideation and attempts, general medical conditions, and global functioning in a prospective 30-year follow-up. Methods: Children and adolescents (N = 158; mean age of first interview = 19.3 years) were followed for up to 30 years (mean age of last interview + 47.3 years) and evaluated 4.8 (SD 1.1) times on average during this period. Final diagnoses were made by a blinded MD or PhD evaluator. A survival analysis was performed to evaluate the hazard ratio for psychiatric disorders for those children and adolescents with DD diagnosis (mean age of onset = 9.6 years) up to 30 years after the first evaluation. Results: Children and adolescents with DD presented a significant higher risk for alcohol use disorder (hazard ratio = 4.28, 95%CI 2.24-8.17, P |
| doi_str_mv | 10.1016/j.jaac.2016.09.052 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1850789625</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0890856716312813</els_id><sourcerecordid>1850789625</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2125-ba70704c8ea03af1eb1b07f715b3db5f58867b110ae7b43cd17efc19ff0d4a9a3</originalsourceid><addsrcrecordid>eNp9ks-K2zAQxk1poem2L9CToJce1u6MbUVyKQXjOIkhGy_5Q9mTkGWZVeq1UynZsi_S563dFAp76GkG5vcN8_GN571HCBBw-ukQHKRUQTj0ASQB0PCFN0EaMp_GyF96E-AJ-JxO2WvvjXMHAEDG-cT7hQFFEoF_p6Ul875t-5_-_kj6hmT3pq2t7ojsapLWfaud0t3JkW_mdE9mxtnz8WQe9dj2ttb2M7nd3mXLIt1tiuyaLPJ1vklXZJmnq93ymszym3KxSW-X4zBdz8i2zIphPt-vs11Rrov1gpT7XVbe5Nu33qtGtk6_-1uvvP0832VLf1Uuiixd-SrEkPqVZMAgVlxLiGSDusIKWMOQVlFd0YZyPmUVIkjNqjhSNTLdKEyaBupYJjK68j5e9h5t_-Os3Uk8mMFl28pO92cnkFNgPJmGdEA_PEMP_dl2w3UDFSMDiGk4UOGFUrZ3zupGHK15kPZJIIgxKnEQY1RijEpAIuCP6MtFpAerj0Zb4ZTRndK1sVqdRN2b_8u_PpOr1nRGyfa7ftLu35nChQLEdvyF8RVwGmHIMYp-A-eNqnE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1841700452</pqid></control><display><type>article</type><title>1.51 30-Year Follow-Up of Children and Adolescents With Disruptive Disorder: PSYCHIATRIC, GENERAL HEALTH, DEMOGRAPHIC, AND SOCIAL FUNCTIONING OUTCOMES</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Diaz, Alexandre Paim, PhD ; Warner, Virginia, DrPH ; Gameroff, Marc J., PhD ; Skipper, Jamie, MA ; Talati, Ardesheer, PhD ; Wickramaratne, Priya, PhD ; Weissman, Myrna M., PhD</creator><creatorcontrib>Diaz, Alexandre Paim, PhD ; Warner, Virginia, DrPH ; Gameroff, Marc J., PhD ; Skipper, Jamie, MA ; Talati, Ardesheer, PhD ; Wickramaratne, Priya, PhD ; Weissman, Myrna M., PhD</creatorcontrib><description>Objectives: Despite evidence in the literature for the risk of developing other psychiatric disorders in children and adolescents with disruptive disorders (DD), the long-term outcomes into adulthood need better clarification. The objective of this study is to evaluate several outcomes for children and adolescents with DD diagnosis, including psychiatric disorders, suicide ideation and attempts, general medical conditions, and global functioning in a prospective 30-year follow-up. Methods: Children and adolescents (N = 158; mean age of first interview = 19.3 years) were followed for up to 30 years (mean age of last interview + 47.3 years) and evaluated 4.8 (SD 1.1) times on average during this period. Final diagnoses were made by a blinded MD or PhD evaluator. A survival analysis was performed to evaluate the hazard ratio for psychiatric disorders for those children and adolescents with DD diagnosis (mean age of onset = 9.6 years) up to 30 years after the first evaluation. Results: Children and adolescents with DD presented a significant higher risk for alcohol use disorder (hazard ratio = 4.28, 95%CI 2.24-8.17, P<0.000), drug use disorder (hazard ratio = 2.96, 95% CI 1.40-6.27, P = 0.004) and depression, which remain significant even controlling for depressive disorder at first or secondwave of evaluation (hazard ratio 1.74, 95%CI 1.12-2.70, P<0.000) in the long-term follow-up. The depression age of onset within those with DD was on average six years earlier than those with no DD diagnosis. Furthermore, suicide ideation (adjusted OR = 2.08, 95%CI 1.00-4.30, P=0.049) and suicidal attempts (adjusted OR = 14.99 95% CI 4.36-51.55, P < 0.000) were associated with DD diagnosis. Finally, significantly more general medical conditions and poorer overall functioning were found in adults diagnosed with DD at younger ages. Conclusions: Children and adolescents with DD showed higher risk for psychiatric disorders; association with suicide ideation, suicide attempts, and more general medical conditions; and worse overall functioning in a 30-year follow-up. Given that diagnostic categories as currently classified are known heterogeneous, transdiagnostic traits shared by patients diagnosed with DD could provide the endophenotype framework from which the biological mechanisms underlying these associations could be investigated.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1016/j.jaac.2016.09.052</identifier><identifier>CODEN: JAAPEE</identifier><language>eng</language><publisher>Baltimore: Elsevier Inc</publisher><subject>Adolescents ; Adults ; Age ; Age of onset ; Alcohol related disorders ; Alcohol use ; Attempted ; Child & adolescent psychiatry ; Children ; Children & youth ; Demographics ; Depression ; Depressive personality disorders ; Diagnosis ; Drug abuse ; Drug Use ; Medical conditions ; Medical diagnosis ; Mental depression ; Mental disorders ; Pediatrics ; Psychiatry ; Social functioning ; Substance use disorder ; Suicidal ideation ; Suicide ; Teenagers</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 2016-10, Vol.55 (10), p.S116-S116</ispartof><rights>2016</rights><rights>Copyright Lippincott Williams & Wilkins Oct 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaac.2016.09.052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,30997,45993</link.rule.ids></links><search><creatorcontrib>Diaz, Alexandre Paim, PhD</creatorcontrib><creatorcontrib>Warner, Virginia, DrPH</creatorcontrib><creatorcontrib>Gameroff, Marc J., PhD</creatorcontrib><creatorcontrib>Skipper, Jamie, MA</creatorcontrib><creatorcontrib>Talati, Ardesheer, PhD</creatorcontrib><creatorcontrib>Wickramaratne, Priya, PhD</creatorcontrib><creatorcontrib>Weissman, Myrna M., PhD</creatorcontrib><title>1.51 30-Year Follow-Up of Children and Adolescents With Disruptive Disorder: PSYCHIATRIC, GENERAL HEALTH, DEMOGRAPHIC, AND SOCIAL FUNCTIONING OUTCOMES</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><description>Objectives: Despite evidence in the literature for the risk of developing other psychiatric disorders in children and adolescents with disruptive disorders (DD), the long-term outcomes into adulthood need better clarification. The objective of this study is to evaluate several outcomes for children and adolescents with DD diagnosis, including psychiatric disorders, suicide ideation and attempts, general medical conditions, and global functioning in a prospective 30-year follow-up. Methods: Children and adolescents (N = 158; mean age of first interview = 19.3 years) were followed for up to 30 years (mean age of last interview + 47.3 years) and evaluated 4.8 (SD 1.1) times on average during this period. Final diagnoses were made by a blinded MD or PhD evaluator. A survival analysis was performed to evaluate the hazard ratio for psychiatric disorders for those children and adolescents with DD diagnosis (mean age of onset = 9.6 years) up to 30 years after the first evaluation. Results: Children and adolescents with DD presented a significant higher risk for alcohol use disorder (hazard ratio = 4.28, 95%CI 2.24-8.17, P<0.000), drug use disorder (hazard ratio = 2.96, 95% CI 1.40-6.27, P = 0.004) and depression, which remain significant even controlling for depressive disorder at first or secondwave of evaluation (hazard ratio 1.74, 95%CI 1.12-2.70, P<0.000) in the long-term follow-up. The depression age of onset within those with DD was on average six years earlier than those with no DD diagnosis. Furthermore, suicide ideation (adjusted OR = 2.08, 95%CI 1.00-4.30, P=0.049) and suicidal attempts (adjusted OR = 14.99 95% CI 4.36-51.55, P < 0.000) were associated with DD diagnosis. Finally, significantly more general medical conditions and poorer overall functioning were found in adults diagnosed with DD at younger ages. Conclusions: Children and adolescents with DD showed higher risk for psychiatric disorders; association with suicide ideation, suicide attempts, and more general medical conditions; and worse overall functioning in a 30-year follow-up. Given that diagnostic categories as currently classified are known heterogeneous, transdiagnostic traits shared by patients diagnosed with DD could provide the endophenotype framework from which the biological mechanisms underlying these associations could be investigated.</description><subject>Adolescents</subject><subject>Adults</subject><subject>Age</subject><subject>Age of onset</subject><subject>Alcohol related disorders</subject><subject>Alcohol use</subject><subject>Attempted</subject><subject>Child & adolescent psychiatry</subject><subject>Children</subject><subject>Children & youth</subject><subject>Demographics</subject><subject>Depression</subject><subject>Depressive personality disorders</subject><subject>Diagnosis</subject><subject>Drug abuse</subject><subject>Drug Use</subject><subject>Medical conditions</subject><subject>Medical diagnosis</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Pediatrics</subject><subject>Psychiatry</subject><subject>Social functioning</subject><subject>Substance use disorder</subject><subject>Suicidal ideation</subject><subject>Suicide</subject><subject>Teenagers</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNp9ks-K2zAQxk1poem2L9CToJce1u6MbUVyKQXjOIkhGy_5Q9mTkGWZVeq1UynZsi_S563dFAp76GkG5vcN8_GN571HCBBw-ukQHKRUQTj0ASQB0PCFN0EaMp_GyF96E-AJ-JxO2WvvjXMHAEDG-cT7hQFFEoF_p6Ul875t-5_-_kj6hmT3pq2t7ojsapLWfaud0t3JkW_mdE9mxtnz8WQe9dj2ttb2M7nd3mXLIt1tiuyaLPJ1vklXZJmnq93ymszym3KxSW-X4zBdz8i2zIphPt-vs11Rrov1gpT7XVbe5Nu33qtGtk6_-1uvvP0832VLf1Uuiixd-SrEkPqVZMAgVlxLiGSDusIKWMOQVlFd0YZyPmUVIkjNqjhSNTLdKEyaBupYJjK68j5e9h5t_-Os3Uk8mMFl28pO92cnkFNgPJmGdEA_PEMP_dl2w3UDFSMDiGk4UOGFUrZ3zupGHK15kPZJIIgxKnEQY1RijEpAIuCP6MtFpAerj0Zb4ZTRndK1sVqdRN2b_8u_PpOr1nRGyfa7ftLu35nChQLEdvyF8RVwGmHIMYp-A-eNqnE</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Diaz, Alexandre Paim, PhD</creator><creator>Warner, Virginia, DrPH</creator><creator>Gameroff, Marc J., PhD</creator><creator>Skipper, Jamie, MA</creator><creator>Talati, Ardesheer, PhD</creator><creator>Wickramaratne, Priya, PhD</creator><creator>Weissman, Myrna M., PhD</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope></search><sort><creationdate>20161001</creationdate><title>1.51 30-Year Follow-Up of Children and Adolescents With Disruptive Disorder: PSYCHIATRIC, GENERAL HEALTH, DEMOGRAPHIC, AND SOCIAL FUNCTIONING OUTCOMES</title><author>Diaz, Alexandre Paim, PhD ; Warner, Virginia, DrPH ; Gameroff, Marc J., PhD ; Skipper, Jamie, MA ; Talati, Ardesheer, PhD ; Wickramaratne, Priya, PhD ; Weissman, Myrna M., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2125-ba70704c8ea03af1eb1b07f715b3db5f58867b110ae7b43cd17efc19ff0d4a9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescents</topic><topic>Adults</topic><topic>Age</topic><topic>Age of onset</topic><topic>Alcohol related disorders</topic><topic>Alcohol use</topic><topic>Attempted</topic><topic>Child & adolescent psychiatry</topic><topic>Children</topic><topic>Children & youth</topic><topic>Demographics</topic><topic>Depression</topic><topic>Depressive personality disorders</topic><topic>Diagnosis</topic><topic>Drug abuse</topic><topic>Drug Use</topic><topic>Medical conditions</topic><topic>Medical diagnosis</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Pediatrics</topic><topic>Psychiatry</topic><topic>Social functioning</topic><topic>Substance use disorder</topic><topic>Suicidal ideation</topic><topic>Suicide</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diaz, Alexandre Paim, PhD</creatorcontrib><creatorcontrib>Warner, Virginia, DrPH</creatorcontrib><creatorcontrib>Gameroff, Marc J., PhD</creatorcontrib><creatorcontrib>Skipper, Jamie, MA</creatorcontrib><creatorcontrib>Talati, Ardesheer, PhD</creatorcontrib><creatorcontrib>Wickramaratne, Priya, PhD</creatorcontrib><creatorcontrib>Weissman, Myrna M., PhD</creatorcontrib><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diaz, Alexandre Paim, PhD</au><au>Warner, Virginia, DrPH</au><au>Gameroff, Marc J., PhD</au><au>Skipper, Jamie, MA</au><au>Talati, Ardesheer, PhD</au><au>Wickramaratne, Priya, PhD</au><au>Weissman, Myrna M., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1.51 30-Year Follow-Up of Children and Adolescents With Disruptive Disorder: PSYCHIATRIC, GENERAL HEALTH, DEMOGRAPHIC, AND SOCIAL FUNCTIONING OUTCOMES</atitle><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle><date>2016-10-01</date><risdate>2016</risdate><volume>55</volume><issue>10</issue><spage>S116</spage><epage>S116</epage><pages>S116-S116</pages><issn>0890-8567</issn><eissn>1527-5418</eissn><coden>JAAPEE</coden><abstract>Objectives: Despite evidence in the literature for the risk of developing other psychiatric disorders in children and adolescents with disruptive disorders (DD), the long-term outcomes into adulthood need better clarification. The objective of this study is to evaluate several outcomes for children and adolescents with DD diagnosis, including psychiatric disorders, suicide ideation and attempts, general medical conditions, and global functioning in a prospective 30-year follow-up. Methods: Children and adolescents (N = 158; mean age of first interview = 19.3 years) were followed for up to 30 years (mean age of last interview + 47.3 years) and evaluated 4.8 (SD 1.1) times on average during this period. Final diagnoses were made by a blinded MD or PhD evaluator. A survival analysis was performed to evaluate the hazard ratio for psychiatric disorders for those children and adolescents with DD diagnosis (mean age of onset = 9.6 years) up to 30 years after the first evaluation. Results: Children and adolescents with DD presented a significant higher risk for alcohol use disorder (hazard ratio = 4.28, 95%CI 2.24-8.17, P<0.000), drug use disorder (hazard ratio = 2.96, 95% CI 1.40-6.27, P = 0.004) and depression, which remain significant even controlling for depressive disorder at first or secondwave of evaluation (hazard ratio 1.74, 95%CI 1.12-2.70, P<0.000) in the long-term follow-up. The depression age of onset within those with DD was on average six years earlier than those with no DD diagnosis. Furthermore, suicide ideation (adjusted OR = 2.08, 95%CI 1.00-4.30, P=0.049) and suicidal attempts (adjusted OR = 14.99 95% CI 4.36-51.55, P < 0.000) were associated with DD diagnosis. Finally, significantly more general medical conditions and poorer overall functioning were found in adults diagnosed with DD at younger ages. Conclusions: Children and adolescents with DD showed higher risk for psychiatric disorders; association with suicide ideation, suicide attempts, and more general medical conditions; and worse overall functioning in a 30-year follow-up. Given that diagnostic categories as currently classified are known heterogeneous, transdiagnostic traits shared by patients diagnosed with DD could provide the endophenotype framework from which the biological mechanisms underlying these associations could be investigated.</abstract><cop>Baltimore</cop><pub>Elsevier Inc</pub><doi>10.1016/j.jaac.2016.09.052</doi></addata></record> |
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| subjects | Adolescents Adults Age Age of onset Alcohol related disorders Alcohol use Attempted Child & adolescent psychiatry Children Children & youth Demographics Depression Depressive personality disorders Diagnosis Drug abuse Drug Use Medical conditions Medical diagnosis Mental depression Mental disorders Pediatrics Psychiatry Social functioning Substance use disorder Suicidal ideation Suicide Teenagers |
| title | 1.51 30-Year Follow-Up of Children and Adolescents With Disruptive Disorder: PSYCHIATRIC, GENERAL HEALTH, DEMOGRAPHIC, AND SOCIAL FUNCTIONING OUTCOMES |
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