1.51 30-Year Follow-Up of Children and Adolescents With Disruptive Disorder: PSYCHIATRIC, GENERAL HEALTH, DEMOGRAPHIC, AND SOCIAL FUNCTIONING OUTCOMES

Objectives: Despite evidence in the literature for the risk of developing other psychiatric disorders in children and adolescents with disruptive disorders (DD), the long-term outcomes into adulthood need better clarification. The objective of this study is to evaluate several outcomes for children and adolescents with DD diagnosis, including psychiatric disorders, suicide ideation and attempts, general medical conditions, and global functioning in a prospective 30-year follow-up. Methods: Children and adolescents (N = 158; mean age of first interview = 19.3 years) were followed for up to 30 years (mean age of last interview + 47.3 years) and evaluated 4.8 (SD 1.1) times on average during this period. Final diagnoses were made by a blinded MD or PhD evaluator. A survival analysis was performed to evaluate the hazard ratio for psychiatric disorders for those children and adolescents with DD diagnosis (mean age of onset = 9.6 years) up to 30 years after the first evaluation. Results: Children and adolescents with DD presented a significant higher risk for alcohol use disorder (hazard ratio = 4.28, 95%CI 2.24-8.17, P