Transmission of Drug-Resistant Leprosy in Guinea-Conakry Detected Using Molecular Epidemiological Approaches
Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium lepra...
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| Veröffentlicht in: | Clinical infectious diseases 2016-12, Vol.63 (11), p.1482-1484 |
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| creator | Avanzi, Charlotte Busso, Philippe Benjak, Andrej Loiseau, Chloé Fomba, Abdoulaye Doumbia, Glodia Camara, Idrissa Lamou, André Sock, Gouressy Drame, Tiguidanké Kodio, Mamadou Sakho, Fatoumata Sow, Samba O. Cole, Stewart T. Johnson, Roch Christian |
| description | Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium leprae, including a rifampicin-resistant strain, is reported. |
| doi_str_mv | 10.1093/cid/ciw572 |
| format | Article |
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We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium leprae, including a rifampicin-resistant strain, is reported.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciw572</identifier><identifier>PMID: 27558568</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Antibiotics, Antitubercular - pharmacology ; Antibiotics, Antitubercular - therapeutic use ; Antitubercular Agents - pharmacology ; Antitubercular Agents - therapeutic use ; Biopsy ; BRIEF REPORTS ; Dapsone - pharmacology ; Dapsone - therapeutic use ; Disease transmission ; DNA, Bacterial - genetics ; Drug resistance ; Drug Resistance, Microbial ; Epidemiology ; Female ; Genome, Bacterial ; Guinea - epidemiology ; Humans ; Leprosy ; Leprosy - epidemiology ; Leprosy - microbiology ; Leprosy - transmission ; Male ; Mycobacterium leprae ; Mycobacterium leprae - drug effects ; Mycobacterium leprae - genetics ; Mycobacterium leprae - isolation & purification ; Rifampin - pharmacology ; Rifampin - therapeutic use ; Sequence Analysis, DNA ; Skin - microbiology ; Skin - pathology</subject><ispartof>Clinical infectious diseases, 2016-12, Vol.63 (11), p.1482-1484</ispartof><rights>Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Dec 1, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26373389$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26373389$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27558568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avanzi, Charlotte</creatorcontrib><creatorcontrib>Busso, Philippe</creatorcontrib><creatorcontrib>Benjak, Andrej</creatorcontrib><creatorcontrib>Loiseau, Chloé</creatorcontrib><creatorcontrib>Fomba, Abdoulaye</creatorcontrib><creatorcontrib>Doumbia, Glodia</creatorcontrib><creatorcontrib>Camara, Idrissa</creatorcontrib><creatorcontrib>Lamou, André</creatorcontrib><creatorcontrib>Sock, Gouressy</creatorcontrib><creatorcontrib>Drame, Tiguidanké</creatorcontrib><creatorcontrib>Kodio, Mamadou</creatorcontrib><creatorcontrib>Sakho, Fatoumata</creatorcontrib><creatorcontrib>Sow, Samba O.</creatorcontrib><creatorcontrib>Cole, Stewart T.</creatorcontrib><creatorcontrib>Johnson, Roch Christian</creatorcontrib><title>Transmission of Drug-Resistant Leprosy in Guinea-Conakry Detected Using Molecular Epidemiological Approaches</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. 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We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium leprae, including a rifampicin-resistant strain, is reported.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>27558568</pmid><doi>10.1093/cid/ciw572</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical infectious diseases, 2016-12, Vol.63 (11), p.1482-1484 |
| issn | 1058-4838 1537-6591 |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antibiotics, Antitubercular - pharmacology Antibiotics, Antitubercular - therapeutic use Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Biopsy BRIEF REPORTS Dapsone - pharmacology Dapsone - therapeutic use Disease transmission DNA, Bacterial - genetics Drug resistance Drug Resistance, Microbial Epidemiology Female Genome, Bacterial Guinea - epidemiology Humans Leprosy Leprosy - epidemiology Leprosy - microbiology Leprosy - transmission Male Mycobacterium leprae Mycobacterium leprae - drug effects Mycobacterium leprae - genetics Mycobacterium leprae - isolation & purification Rifampin - pharmacology Rifampin - therapeutic use Sequence Analysis, DNA Skin - microbiology Skin - pathology |
| title | Transmission of Drug-Resistant Leprosy in Guinea-Conakry Detected Using Molecular Epidemiological Approaches |
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