Transmission of Drug-Resistant Leprosy in Guinea-Conakry Detected Using Molecular Epidemiological Approaches

Transmission of Drug-Resistant Leprosy in Guinea-Conakry Detected Using Molecular Epidemiological Approaches

Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium lepra...

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Veröffentlicht in:Clinical infectious diseases 2016-12, Vol.63 (11), p.1482-1484
Hauptverfasser: Avanzi, Charlotte, Busso, Philippe, Benjak, Andrej, Loiseau, Chloé, Fomba, Abdoulaye, Doumbia, Glodia, Camara, Idrissa, Lamou, André, Sock, Gouressy, Drame, Tiguidanké, Kodio, Mamadou, Sakho, Fatoumata, Sow, Samba O., Cole, Stewart T., Johnson, Roch Christian
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics, Antitubercular - pharmacology
Antibiotics, Antitubercular - therapeutic use
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Biopsy
BRIEF REPORTS
Dapsone - pharmacology
Dapsone - therapeutic use
Disease transmission
DNA, Bacterial - genetics
Drug resistance
Drug Resistance, Microbial
Epidemiology
Female
Genome, Bacterial
Guinea - epidemiology
Humans
Leprosy
Leprosy - epidemiology
Leprosy - microbiology
Leprosy - transmission
Male
Mycobacterium leprae
Mycobacterium leprae - drug effects
Mycobacterium leprae - genetics
Mycobacterium leprae - isolation & purification
Rifampin - pharmacology
Rifampin - therapeutic use
Sequence Analysis, DNA
Skin - microbiology
Skin - pathology
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Zusammenfassung:Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium leprae, including a rifampicin-resistant strain, is reported.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciw572