A MVA construct expressing a secretable form of the Dengue virus 3 envelope protein protects immunized mice from dengue-induced encephalitis

Highlights • MVA expressing a DENV protein directed to the ER induces neutralizing antibodies. • Vaccination with MVA expressing a secretable E protein abrogates encephalitis in mice. • MVA expressing a non-secretable E protein does not protect mice from encephalitis.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-12, Vol.34 (50), p.6120-6122
Hauptverfasser:	Quinan, Bárbara R, Versiani, Alice Freitas, da Fonseca, Flávio G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Dengue - prevention & control Dengue fever Dengue vaccine Dengue Vaccines - administration & dosage Dengue Vaccines - genetics Dengue Vaccines - immunology Dengue Virus - genetics Dengue Virus - immunology Developing countries Disease Models, Animal Drug Carriers Encephalitis Encephalitis model Encephalitis, Viral - prevention & control Experiments Female Flaviviridae Glycoproteins Immunization Immunogenicity Infections LDCs Licenses Lymphocytes Mice Mice, Inbred C57BL MVA Neutralizing antibodies Peptides Proteins Public health Recombinant MVA Studies Vaccines Vaccinia virus Vaccinia virus - genetics Vector-borne diseases Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology
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Beschreibung
Zusammenfassung:	Highlights • MVA expressing a DENV protein directed to the ER induces neutralizing antibodies. • Vaccination with MVA expressing a secretable E protein abrogates encephalitis in mice. • MVA expressing a non-secretable E protein does not protect mice from encephalitis.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.10.058