Effects of pretransplant sarcopenia and sequential changes in sarcopenic parameters after living donor liver transplantation

Sarcopenia is characterized by muscle mass depletion and decrease in muscle power or physical activity. We previously reported that low skeletal muscle mass (SMM) is closely involved with posttransplant mortality in patients undergoing living donor liver transplantation (LDLT). The aim of this study...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2017-01, Vol.33, p.195-198
Hauptverfasser:	Kaido, Toshimi, Tamai, Yumiko, Hamaguchi, Yuhei, Okumura, Shinya, Kobayashi, Atsushi, Shirai, Hisaya, Yagi, Shintaro, Kamo, Naoko, Hammad, Ahmed, Inagaki, Nobuya, Uemoto, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Body Composition Cohort Studies Disease Progression Female Grip strength Hand Strength Hepatitis Hospitals, University Humans Japan - epidemiology Liver cirrhosis Liver Failure, Acute - complications Liver Failure, Acute - surgery Liver transplantation Liver Transplantation - adverse effects Living Donors Male Medical imaging Middle Aged Mortality Musculoskeletal system Nutrition Patient Selection Patients Postoperative Period Practice Guidelines as Topic Prospective Studies Quality Rehabilitation Sarcopenia Sarcopenia - complications Sarcopenia - physiopathology Skeletal muscle mass Studies Survival Survival Analysis Young Adult
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Zusammenfassung:	Sarcopenia is characterized by muscle mass depletion and decrease in muscle power or physical activity. We previously reported that low skeletal muscle mass (SMM) is closely involved with posttransplant mortality in patients undergoing living donor liver transplantation (LDLT). The aim of this study was to prospectively investigate the effects of pretransplant sarcopenia on survival and examine sequential changes in sarcopenic parameters after LDLT. Sarcopenia was defined by measuring SMM using a multifrequency body composition analyzer and assessing grip strength (GS) in 72 adults who underwent LDLT at Kyoto University Hospital between January 2013 and October 2015. The effects of pretransplant sarcopenia on short-term survival and sequential changes in SMM and GS were prospectively analyzed. Of 72 patients, 10 (14%) were defined as having pretransplant sarcopenia. Overall survival rates were significantly lower in patients with sarcopenia (n = 10) than those without sarcopenia (n = 62; P
ISSN:	0899-9007 1873-1244
DOI:	10.1016/j.nut.2016.07.002