miRNA as activity markers in Parvo B19 associated heart disease

miRNA as activity markers in Parvo B19 associated heart disease

Parvovirus B19 is a frequent virus detected in endomyocardial biopsies of patients with clinically suspected myocarditis or dilated cardiomyopathy (DCM). Viruses often cause a more symptomatic disease with increased tissue injury if they become reactivated. A disease-specific differential expression...

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Veröffentlicht in:Herz 2012-09, Vol.37 (6), p.637-643
Hauptverfasser: Kühl, U., Rohde, M., Lassner, D., Gross, U.M., Escher, F., Schultheiss, H.-P.
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiomyopathies - diagnosis
Cardiomyopathies - genetics
Cardiomyopathies - virology
Female
Genetic Markers - genetics
Humans
Internal Medicine
Main Topic
Male
Medicine
Medicine & Public Health
MicroRNAs - genetics
Middle Aged
Parvoviridae
Parvoviridae Infections - diagnosis
Parvoviridae Infections - genetics
Parvoviridae Infections - virology
Parvovirus B19, Human - isolation & purification
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Beschreibung
Zusammenfassung:Parvovirus B19 is a frequent virus detected in endomyocardial biopsies of patients with clinically suspected myocarditis or dilated cardiomyopathy (DCM). Viruses often cause a more symptomatic disease with increased tissue injury if they become reactivated. A disease-specific differential expression of microRNAs (miRNAs) has been described in the regulation of replicating viruses. Analyzing patients with latent and reactivated B19V infection, we found 29 differentially regulated miRNAs and, in order to test whether predicted genes are differentially expressed, selected mRNAs were tested by TaqMan-QPCR.
ISSN:0340-9937
1615-6692
DOI:10.1007/s00059-012-3656-3