Modular virus-like particles for sublingual vaccination against group A streptococcus

Highlights • Sublingual vaccination with modular VLPs elicited systemic and mucosal antibodies. • Cholera toxin enhanced IgA level induced by sublingually vaccinated modular VLPs. • Freeze-dried modular VLPs induced high levels of J8i-specific IgG antibody. • Adjuvanted freeze-dried modular VLPs gen...

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Veröffentlicht in:	Vaccine 2016-12, Vol.34 (51), p.6472-6480
Hauptverfasser:	Seth, Arjun, Kong, Il Gyu, Lee, Su-Hyun, Yang, Jin-Young, Lee, Yong-Soo, Kim, Yeji, Wibowo, Nani, Middelberg, Anton P.J, Lua, Linda H.L, Kweon, Mi-Na
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Administration, Sublingual Allergy and Immunology Animals Antibodies, Bacterial - analysis Antibodies, Bacterial - blood Antigens Cholera Toxin - administration & dosage Developed countries Developing countries Experiments Female Freeze drying Group A streptococcus Human papillomavirus Immunization Immunoglobulin A - analysis Immunoglobulin G - blood Immunoglobulins In vivo imaging LDCs Lymph nodes Mice, Inbred BALB C Mucosal vaccine Opsonin Proteins - analysis Peptides Performance evaluation Saliva - immunology Serum - immunology Streptococcal Infections - prevention & control Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - genetics Streptococcal Vaccines - immunology Streptococcus Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology Studies Sublingual administration Toxins Vaccine Vaccines Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - genetics Vaccines, Virus-Like Particle - immunology Virus-like particles Waterborne diseases
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Beschreibung
Zusammenfassung:	Highlights • Sublingual vaccination with modular VLPs elicited systemic and mucosal antibodies. • Cholera toxin enhanced IgA level induced by sublingually vaccinated modular VLPs. • Freeze-dried modular VLPs induced high levels of J8i-specific IgG antibody. • Adjuvanted freeze-dried modular VLPs generated opsonization antibodies.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.11.008