A current snapshot of common genomic variants contribution in psychiatric disorders

In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polyg...

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2016-12, Vol.171B (8), p.997-1005
Hauptverfasser:	Santoro, Marcos L., Moretti, Patricia N., Pellegrino, Renata, Gadelha, Ary, Abílio, Vanessa C., Hayashi, Mirian A.F., Belangero, Sintia I., Hakonarson, Hakon
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Predisposition to Disease - genetics Genetic Variation Genetics Genome-Wide Association Study - methods Genomics GWAS Humans Mental Disorders - genetics Mental Disorders - psychology Multifactorial Inheritance - genetics polygenic risk score Polymorphism, Single Nucleotide - genetics psychiatric disorder psychiatry Risk Factors
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Beschreibung
Zusammenfassung:	In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. © 2016 Wiley Periodicals, Inc.
ISSN:	1552-4841 1552-485X
DOI:	10.1002/ajmg.b.32475