NK cell effector functions in a Chédiak-Higashi patient undergoing cord blood transplantation: effects of in vitro treatment with IL-2

Highlights • NK cell functions in Chédiak-Higashi Syndrome (CHS) are strongly affected. • Restoration of NK cell activities might represent a therapeutic strategy for these patients. • Herein we describe the effector functions of NK cells obtained from a CHS patient receiving umbilical cord blood (U...

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Veröffentlicht in:	Immunology letters 2016-12, Vol.180, p.46-53
Hauptverfasser:	Cifaldi, Loredana, Pinto, Rita Maria, Rana, Ippolita, Caniglia, Maurizio, Angioni, Adriano, Petrocchi, Stefano, Cancrini, Caterina, Cursi, Laura, Palumbo, Giuseppe, Zingoni, Alessandra, Gismondi, Angela, Rossi, Paolo, Santoni, Angela, Cerboni, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibody-Dependent Cell Cytotoxicity - immunology Cell Line Cellular immunology Chediak-Higashi Syndrome - drug therapy Chediak-Higashi Syndrome - immunology Cord blood transplantation Cytotoxicity, Immunologic - immunology Fetal Blood - cytology Fetal Blood - immunology Hematopoietic Stem Cell Transplantation - methods Humans Immunodeficiency Infant Interleukin 2 Interleukin-2 - therapeutic use Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Male NK cells
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