MiR-130b promotes obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through alleviating M2 macrophage polarization via repression of PPAR-γ

Highlights • Mice fed on high-fat diet demonstrated significantly higher body weight and impaired glucose tolerance. • MiR-130b level was up-regulated in macrophage of high-fat diet mice. • PPAR-γ as a miR-130b target gene and regulated macrophage polarization.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2016-12, Vol.180, p.1-8
Hauptverfasser:	Zhang, Min, Zhou, Zhongqi, Wang, Jinguang, Li, Shufa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adipose Tissue - pathology Allergy and Immunology Animals Body Weight - physiology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diet, High-Fat - adverse effects Female Glucose - metabolism Glucose Tolerance Test - methods Inflammation Inflammation - metabolism Inflammation - pathology Insulin - metabolism Insulin Resistance - physiology M2 polarization Macrophages - metabolism Mice Mice, Inbred C57BL MicroRNAs - metabolism MiR-130b Obesity Obesity - metabolism Obesity - pathology PPAR gamma - metabolism PPAR-γ Up-Regulation - physiology
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Beschreibung
Zusammenfassung:	Highlights • Mice fed on high-fat diet demonstrated significantly higher body weight and impaired glucose tolerance. • MiR-130b level was up-regulated in macrophage of high-fat diet mice. • PPAR-γ as a miR-130b target gene and regulated macrophage polarization.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.10.004