ZnT8107-115 /HLA-A2 dimers attenuate the severity of diabetes by inducing CD8 + T cell tolerance

ZnT8107-115 /HLA-A2 dimers attenuate the severity of diabetes by inducing CD8 + T cell tolerance

Highlights • ZnT8107-115 /HLA-A2 dimers inhibited proliferation, cytotoxicity, and inflammatory cytokine of CD8+ T. • ZnT8107-115 /HLA-A2 dimers ameliorated the incidence and severity of diabetes mice. • ZnT8107-115 /HLA-A2 dimers abrogate pathogenic CD8+ T cells in diabetes.

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Bibliographische Detailangaben
Veröffentlicht in:Immunology letters 2016-12, Vol.180, p.66-72
Hauptverfasser: Zhang, Min, Zhou, Zhongqi, Wang, Jinguang, Li, Shufa
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
CD8+T cell
Diabetes
HLA-A2
Tolerance
ZnT8
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Zusammenfassung:Highlights • ZnT8107-115 /HLA-A2 dimers inhibited proliferation, cytotoxicity, and inflammatory cytokine of CD8+ T. • ZnT8107-115 /HLA-A2 dimers ameliorated the incidence and severity of diabetes mice. • ZnT8107-115 /HLA-A2 dimers abrogate pathogenic CD8+ T cells in diabetes.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.11.002