Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice

Highlights • Oral administration of BDE-209 induced antispermatogenic effects in P mice. • Results show that BDE-209 treatment interferes with testicular steroidogenesis. • Inhibition of steroidogenesis is mainly due to the decreased expression of SF-1. • Decreased steroidogenic activity is partly a...

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Veröffentlicht in:	General and comparative endocrinology 2016-12, Vol.239, p.50-61
Hauptverfasser:	Sarkar, Debarshi, Chowdhury, Jayita Pal, Singh, Shio Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases Animals BDE-209 Cholesterol Side-Chain Cleavage Enzyme - metabolism Endocrine Disruptors - pharmacology Endocrinology & Metabolism Epididymis - drug effects Epididymis - metabolism Flame Retardants - pharmacology Gonadal Steroid Hormones - biosynthesis Halogenated Diphenyl Ethers - pharmacology Male Mice Seminiferous Tubules - drug effects Seminiferous Tubules - metabolism Spermatogenesis Spermatogenesis - drug effects Spermatozoa - drug effects Spermatozoa - metabolism Testis Testis - drug effects Testis - metabolism Testosterone Testosterone - blood Thyroid Diseases - chemically induced Thyroid Diseases - metabolism Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid hormones Thyroid Hormones - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Oral administration of BDE-209 induced antispermatogenic effects in P mice. • Results show that BDE-209 treatment interferes with testicular steroidogenesis. • Inhibition of steroidogenesis is mainly due to the decreased expression of SF-1. • Decreased steroidogenic activity is partly associated with altered thyroid status. • BDE-209 induced impairment in testicular steroidogenesis is shown for first time.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.11.009