Administration of the Oral Antibiotic Frenolicin-B Selectively Alters Copper Nutriture in Male Rats

Administration of the Oral Antibiotic Frenolicin-B Selectively Alters Copper Nutriture in Male Rats

The polyketide antibiotic Frenolicin-B (FB) produces anorexia and esophageal epithelial hyperplasia (EH) in rats, findings that are characteristic of zinc deficiency. Because FB also chelates divalent cations in vitro, we conducted studies to determine whether FB modifies blood and organ concentrati...

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Veröffentlicht in:The Journal of nutrition 2001-12, Vol.131 (12), p.3247-3250
Hauptverfasser: Kossor, David C., Han, Shenggao, Kemp, Francis W., Slauter, Richard W., Serota, David, Rajaskarian, Daniel, Milner, Nicholas, Davidovich, Alberto, Bogden, John D.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
anorexia
Anti-Bacterial Agents - adverse effects
Antibiotics
Biological and medical sciences
blood
Brain Chemistry
calcium
cations
chelates
chelation
Copper
Copper - analysis
Copper - deficiency
Diet
Drug toxicity and drugs side effects treatment
Epithelium - pathology
Esophagus - chemistry
Esophagus - pathology
Femur - chemistry
Frenolicin-B
histopathology
Hyperplasia
iron
Iron - analysis
Iron - deficiency
Kidney - chemistry
Kidney - pathology
kidneys
magnesium
Magnesium - analysis
Magnesium Deficiency - chemically induced
Medical sciences
Naphthoquinones - adverse effects
Nutrition
oral administration
Organ Size - drug effects
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Rodents
Salivary Glands - chemistry
Salivary Glands - pathology
stomach
Stomach - chemistry
Stomach - pathology
Tongue - chemistry
Tongue - pathology
Toxicity: digestive system
zinc
Zinc - administration & dosage
Zinc - analysis
Zinc - deficiency
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Zusammenfassung:The polyketide antibiotic Frenolicin-B (FB) produces anorexia and esophageal epithelial hyperplasia (EH) in rats, findings that are characteristic of zinc deficiency. Because FB also chelates divalent cations in vitro, we conducted studies to determine whether FB modifies blood and organ concentrations of zinc and other essential metals (calcium, copper, iron and magnesium). Groups of male Sprague-Dawley rats (∼250g; n = 20/group) consumed diets with adequate (40 μg/g), deficient (
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/131.12.3247