Application of CD8+ Cells Count as a Guide of Immunosuppressive Regimen Introduction for Very Sick Patients Undergoing Liver Transplantation

Application of CD8+ Cells Count as a Guide of Immunosuppressive Regimen Introduction for Very Sick Patients Undergoing Liver Transplantation

Abstract Background Immunosuppression (IS) protocols should be individualized according to the individual recipient's immunity to minimize adverse effects. The aim of this study was to determine whether preoperative levels of CD8+ T lymphocytes could be used as a guide for the introduction of I...

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Veröffentlicht in:Transplantation proceedings 2016-12, Vol.48 (10), p.3356-3361
Hauptverfasser: Lee, C.-F, Wang, Y.-C, Cheng, C.-H, Wu, T.-H, Chen, Y.-C, Soong, R.-S, Wu, T.-J, Chou, H.-S, Chan, K.-M, Lee, W.-C
Format: Artikel
Sprache:eng
Schlagworte:
Adult
CD8-Positive T-Lymphocytes
Clinical Protocols
Female
Graft Rejection - blood
Graft Rejection - drug therapy
Humans
Immunosuppression - methods
Immunosuppressive Agents - administration & dosage
Liver Diseases - blood
Liver Diseases - surgery
Liver Transplantation
Lymphocyte Count
Male
Middle Aged
Preoperative Period
Retrospective Studies
Surgery
Survival Rate
Time Factors
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Zusammenfassung:Abstract Background Immunosuppression (IS) protocols should be individualized according to the individual recipient's immunity to minimize adverse effects. The aim of this study was to determine whether preoperative levels of CD8+ T lymphocytes could be used as a guide for the introduction of IS. Methods Sixteen adult liver transplantations in our institute were retrospectively analyzed. The immunosuppressive agents were temporarily withheld for 8 patients with a lower (
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2016.09.038