The effect of the NMDA receptor-dependent signaling pathway on cell morphology and melanosome transfer in melanocytes

Highlights • NMDA receptor-dependent signaling regulates cell morphology in melanocyte. • NMDA receptor-dependent signaling regulates melanosome transfer in melanocytes. • NMDA receptor antagonist MK-801 blocks calcium influx in melanocyte. • NMDA receptor antagonist MK-801 leads to β-tubulin distri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of dermatological science 2016-12, Vol.84 (3), p.296-304
Hauptverfasser:	Ni, Jing, Wang, Nan, Gao, Lili, Li, Lili, Zheng, Siwen, Liu, Yuejian, Ozukum, Molu, Nikiforova, Anna, Zhao, Guangming, Song, Zhiqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium influx Coculture Techniques Cytoskeleton - metabolism Dendrite Dermatology Dizocilpine Maleate - chemistry Epidermis - metabolism Filopodia Humans Keratinocytes - cytology Melanins - metabolism Melanocytes - cytology Melanosome transfer Melanosomes - metabolism Microscopy, Confocal Microscopy, Electron, Scanning Nerve Tissue Proteins - metabolism NMDA receptor Pigmentation Pseudopodia - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction Skin Diseases - metabolism Tubulin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • NMDA receptor-dependent signaling regulates cell morphology in melanocyte. • NMDA receptor-dependent signaling regulates melanosome transfer in melanocytes. • NMDA receptor antagonist MK-801 blocks calcium influx in melanocyte. • NMDA receptor antagonist MK-801 leads to β-tubulin distribution in melanocyte. • The results of this study are crucial for designing treatments for the pigmentary dermatosis.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2016.08.534