Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging

Highlights • Mean Kurtosis is sensitive to detect early α-Syn accumulation associated changes. • Mean Kurtosis might be best differentiator between gray and white matter changes. • DKI may help in early diagnosis of Parkinson’s disease patients. • DKI might be sensitive to detect progression of path...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.197-208
Hauptverfasser:	Khairnar, Amit, Ruda-Kucerova, Jana, Szabó, Nikoletta, Drazanova, Eva, Arab, Anas, Hutter-Paier, Birgit, Neddens, Joerg, Latta, Peter, Starcuk, Zenon, Rektorova, Irena
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology alpha-Synuclein - genetics alpha-Synuclein - metabolism Animal model Animals Brain - diagnostic imaging Brain - metabolism Diffusion kurtosis imaging Diffusion Magnetic Resonance Imaging Disease Models, Animal Memory - physiology Mice Motor Activity - physiology Motor Skills - physiology MRI Parkinson Disease - diagnostic imaging Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson’s disease Psychiatry Striatum Substantia nigra Thalamus TNWT-61 Transgenic mice
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Zusammenfassung:	Highlights • Mean Kurtosis is sensitive to detect early α-Syn accumulation associated changes. • Mean Kurtosis might be best differentiator between gray and white matter changes. • DKI may help in early diagnosis of Parkinson’s disease patients. • DKI might be sensitive to detect progression of pathology in Parkinson’s disease.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.11.027