Behavioral and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat

Highlights • Chronic antibiotic treatment affects visceral pain and CNS monoamine levels. • Distinct behavioral profile after microbiota depletion. • No change in anxiety and HPA axis.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-12, Vol.339, p.463-477
Hauptverfasser:	Hoban, A.E, Moloney, R.D, Golubeva, A.V, McVey Neufeld, K.A, O’Sullivan, O, Patterson, E, Stanton, C, Dinan, T.G, Clarke, G, Cryan, J.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology antibiotics Anxiety - microbiology Brain - metabolism brain monoamines Brain-Derived Neurotrophic Factor - metabolism Cecum - drug effects Cecum - metabolism cognition Corticosterone - blood Depression - metabolism Depression - microbiology depressive-like behaviours Feces - microbiology Gastrointestinal Microbiome - drug effects Gene Expression Regulation - physiology gut microbiota Male Memory Disorders - metabolism Memory Disorders - microbiology Neurology Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone - metabolism Receptors, Glucocorticoid - metabolism RNA, Messenger - metabolism Serotonin - metabolism Visceral Pain - metabolism Visceral Pain - microbiology Visceral Pain - psychology visceral sensitivity
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Beschreibung
Zusammenfassung:	Highlights • Chronic antibiotic treatment affects visceral pain and CNS monoamine levels. • Distinct behavioral profile after microbiota depletion. • No change in anxiety and HPA axis.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.10.003