Pulmonary vein reconnection following catheter ablation of atrial fibrillation using the second-generation cryoballoon versus open-irrigated radiofrequency: results of a multicenter analysis

Purpose Catheter ablation of atrial fibrillation (CAAF) using the cryoballoon has emerged as an alternate strategy to point-by-point radiofrequency. However, there is little comparative data on long-term durability of pulmonary vein (PV) isolation comparing these two modalities. Methods In this mult...

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Veröffentlicht in:Journal of interventional cardiac electrophysiology 2016-12, Vol.47 (3), p.341-348
Hauptverfasser: Aryana, Arash, Singh, Sheldon M., Mugnai, Giacomo, de Asmundis, Carlo, Kowalski, Marcin, Pujara, Deep K., Cohen, Andrew I., Singh, Steve K., Fuenzalida, Charles E., Prager, Nelson, Bowers, Mark R., O’Neill, Padraig Gearoid, Brugada, Pedro, d’Avila, André, Chierchia, Gian-Battista
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container_end_page 348
container_issue 3
container_start_page 341
container_title Journal of interventional cardiac electrophysiology
container_volume 47
creator Aryana, Arash
Singh, Sheldon M.
Mugnai, Giacomo
de Asmundis, Carlo
Kowalski, Marcin
Pujara, Deep K.
Cohen, Andrew I.
Singh, Steve K.
Fuenzalida, Charles E.
Prager, Nelson
Bowers, Mark R.
O’Neill, Padraig Gearoid
Brugada, Pedro
d’Avila, André
Chierchia, Gian-Battista
description Purpose Catheter ablation of atrial fibrillation (CAAF) using the cryoballoon has emerged as an alternate strategy to point-by-point radiofrequency. However, there is little comparative data on long-term durability of pulmonary vein (PV) isolation comparing these two modalities. Methods In this multicenter, retrospective analysis, the incidences/patterns of late PV reconnection following an index CAAF using the second-generation cryoballoon versus open-irrigated, non-force-sensing radiofrequency were examined. Results Of the 2002 patients who underwent a first-time CAAF, 186/1126 patients (16.5 %) ablated using cryoballoon and 174/876 patients (19.9 %) with non-contact force-guided radiofrequency required a repeat procedure at 11 ± 5 months. During follow-up, the incidence of atrial flutters/tachycardias was lower (19.9 vs. 32.8 %; p  = 0.005) and fewer patients exhibited PV reconnection (47.3 vs. 60.9 %; p  = 0.007) with cryoballoon versus radiofrequency. Additionally, fewer PVs had reconnected with cryoballoon versus radiofrequency (18.8 vs. 34.6 %; p  
doi_str_mv 10.1007/s10840-016-0172-z
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However, there is little comparative data on long-term durability of pulmonary vein (PV) isolation comparing these two modalities. Methods In this multicenter, retrospective analysis, the incidences/patterns of late PV reconnection following an index CAAF using the second-generation cryoballoon versus open-irrigated, non-force-sensing radiofrequency were examined. Results Of the 2002 patients who underwent a first-time CAAF, 186/1126 patients (16.5 %) ablated using cryoballoon and 174/876 patients (19.9 %) with non-contact force-guided radiofrequency required a repeat procedure at 11 ± 5 months. During follow-up, the incidence of atrial flutters/tachycardias was lower (19.9 vs. 32.8 %; p  = 0.005) and fewer patients exhibited PV reconnection (47.3 vs. 60.9 %; p  = 0.007) with cryoballoon versus radiofrequency. Additionally, fewer PVs had reconnected with cryoballoon versus radiofrequency (18.8 vs. 34.6 %; p  &lt; 0.001). With cryoballoon, the right inferior ( p  &lt; 0.001) and left common ( p  = 0.039) PVs were more likely to exhibit late reconnection, versus the left superior PV with radiofrequency ( p  = 0.012). However, when comparing the two strategies, the left common PV was more likely to exhibit reconnection with cryoballoon, whereas all other PVs with the exception of the right inferior PV demonstrated a lower reconnection rate with cryoballoon versus radiofrequency. Lastly, in a logistic regression multivariate analysis, cryoballoon ablation and PV ablation time emerged as significant predictors of durable PV isolation at repeat procedure. Conclusions In this large multicenter, retrospective analysis, CAAF using the second-generation cryoballoon was associated with improved durability of PV isolation compared to open-irrigated, non-force-sensing radiofrequency.</description><identifier>ISSN: 1383-875X</identifier><identifier>EISSN: 1572-8595</identifier><identifier>DOI: 10.1007/s10840-016-0172-z</identifier><identifier>PMID: 27475949</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Atrial Fibrillation - diagnosis ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - surgery ; Cardiology ; Catheter Ablation - instrumentation ; Catheter Ablation - utilization ; Cryosurgery - instrumentation ; Cryosurgery - utilization ; Equipment Design ; Equipment Failure Analysis ; Female ; Heart Conduction System - surgery ; Humans ; Incidence ; Internationality ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Operative Time ; Prevalence ; Pulmonary Veins - surgery ; Recurrence ; Risk Factors ; Therapeutic Irrigation - utilization ; Treatment Failure ; Treatment Outcome</subject><ispartof>Journal of interventional cardiac electrophysiology, 2016-12, Vol.47 (3), p.341-348</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Journal of Interventional Cardiac Electrophysiology is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-e072d920476ab43db4462096dc82b1da48e799b838d1a9d2c647e6672e89311e3</citedby><cites>FETCH-LOGICAL-c471t-e072d920476ab43db4462096dc82b1da48e799b838d1a9d2c647e6672e89311e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10840-016-0172-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10840-016-0172-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27475949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aryana, Arash</creatorcontrib><creatorcontrib>Singh, Sheldon M.</creatorcontrib><creatorcontrib>Mugnai, Giacomo</creatorcontrib><creatorcontrib>de Asmundis, Carlo</creatorcontrib><creatorcontrib>Kowalski, Marcin</creatorcontrib><creatorcontrib>Pujara, Deep K.</creatorcontrib><creatorcontrib>Cohen, Andrew I.</creatorcontrib><creatorcontrib>Singh, Steve K.</creatorcontrib><creatorcontrib>Fuenzalida, Charles E.</creatorcontrib><creatorcontrib>Prager, Nelson</creatorcontrib><creatorcontrib>Bowers, Mark R.</creatorcontrib><creatorcontrib>O’Neill, Padraig Gearoid</creatorcontrib><creatorcontrib>Brugada, Pedro</creatorcontrib><creatorcontrib>d’Avila, André</creatorcontrib><creatorcontrib>Chierchia, Gian-Battista</creatorcontrib><title>Pulmonary vein reconnection following catheter ablation of atrial fibrillation using the second-generation cryoballoon versus open-irrigated radiofrequency: results of a multicenter analysis</title><title>Journal of interventional cardiac electrophysiology</title><addtitle>J Interv Card Electrophysiol</addtitle><addtitle>J Interv Card Electrophysiol</addtitle><description>Purpose Catheter ablation of atrial fibrillation (CAAF) using the cryoballoon has emerged as an alternate strategy to point-by-point radiofrequency. However, there is little comparative data on long-term durability of pulmonary vein (PV) isolation comparing these two modalities. Methods In this multicenter, retrospective analysis, the incidences/patterns of late PV reconnection following an index CAAF using the second-generation cryoballoon versus open-irrigated, non-force-sensing radiofrequency were examined. Results Of the 2002 patients who underwent a first-time CAAF, 186/1126 patients (16.5 %) ablated using cryoballoon and 174/876 patients (19.9 %) with non-contact force-guided radiofrequency required a repeat procedure at 11 ± 5 months. During follow-up, the incidence of atrial flutters/tachycardias was lower (19.9 vs. 32.8 %; p  = 0.005) and fewer patients exhibited PV reconnection (47.3 vs. 60.9 %; p  = 0.007) with cryoballoon versus radiofrequency. Additionally, fewer PVs had reconnected with cryoballoon versus radiofrequency (18.8 vs. 34.6 %; p  &lt; 0.001). With cryoballoon, the right inferior ( p  &lt; 0.001) and left common ( p  = 0.039) PVs were more likely to exhibit late reconnection, versus the left superior PV with radiofrequency ( p  = 0.012). However, when comparing the two strategies, the left common PV was more likely to exhibit reconnection with cryoballoon, whereas all other PVs with the exception of the right inferior PV demonstrated a lower reconnection rate with cryoballoon versus radiofrequency. Lastly, in a logistic regression multivariate analysis, cryoballoon ablation and PV ablation time emerged as significant predictors of durable PV isolation at repeat procedure. 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However, there is little comparative data on long-term durability of pulmonary vein (PV) isolation comparing these two modalities. Methods In this multicenter, retrospective analysis, the incidences/patterns of late PV reconnection following an index CAAF using the second-generation cryoballoon versus open-irrigated, non-force-sensing radiofrequency were examined. Results Of the 2002 patients who underwent a first-time CAAF, 186/1126 patients (16.5 %) ablated using cryoballoon and 174/876 patients (19.9 %) with non-contact force-guided radiofrequency required a repeat procedure at 11 ± 5 months. During follow-up, the incidence of atrial flutters/tachycardias was lower (19.9 vs. 32.8 %; p  = 0.005) and fewer patients exhibited PV reconnection (47.3 vs. 60.9 %; p  = 0.007) with cryoballoon versus radiofrequency. Additionally, fewer PVs had reconnected with cryoballoon versus radiofrequency (18.8 vs. 34.6 %; p  &lt; 0.001). With cryoballoon, the right inferior ( p  &lt; 0.001) and left common ( p  = 0.039) PVs were more likely to exhibit late reconnection, versus the left superior PV with radiofrequency ( p  = 0.012). However, when comparing the two strategies, the left common PV was more likely to exhibit reconnection with cryoballoon, whereas all other PVs with the exception of the right inferior PV demonstrated a lower reconnection rate with cryoballoon versus radiofrequency. Lastly, in a logistic regression multivariate analysis, cryoballoon ablation and PV ablation time emerged as significant predictors of durable PV isolation at repeat procedure. Conclusions In this large multicenter, retrospective analysis, CAAF using the second-generation cryoballoon was associated with improved durability of PV isolation compared to open-irrigated, non-force-sensing radiofrequency.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27475949</pmid><doi>10.1007/s10840-016-0172-z</doi><tpages>8</tpages></addata></record>
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subjects Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Atrial Fibrillation - surgery
Cardiology
Catheter Ablation - instrumentation
Catheter Ablation - utilization
Cryosurgery - instrumentation
Cryosurgery - utilization
Equipment Design
Equipment Failure Analysis
Female
Heart Conduction System - surgery
Humans
Incidence
Internationality
Male
Medicine
Medicine & Public Health
Middle Aged
Operative Time
Prevalence
Pulmonary Veins - surgery
Recurrence
Risk Factors
Therapeutic Irrigation - utilization
Treatment Failure
Treatment Outcome
title Pulmonary vein reconnection following catheter ablation of atrial fibrillation using the second-generation cryoballoon versus open-irrigated radiofrequency: results of a multicenter analysis
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