Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage

Highlights • MPSS treatment after ICH reduces BBB disruption and brain oedema. • MPSS also inhibits production of inflammatory cytokines and inflammation in the brain. • MPSS reduces apoptosis in the brain, perhaps by decreasing Bax and increasing Bcl-2. • This suggests that MPSS may be a useful tre...

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Veröffentlicht in:	Brain research bulletin 2016-10, Vol.127, p.226-233
Hauptverfasser:	Cheng, Shiqi, Gao, WeiWei, Xu, Xin, Fan, Hengyi, Wu, Yingang, Li, Fei, Zhang, Jianning, Zhu, Xingen, Zhang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Astrocytes - drug effects Astrocytes - immunology Astrocytes - pathology Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - immunology Blood-Brain Barrier - pathology Brain Edema - drug therapy Brain Edema - immunology Brain Edema - pathology Cytokines - metabolism Disease Models, Animal ICH Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Intracranial Hemorrhages - drug therapy Intracranial Hemorrhages - immunology Intracranial Hemorrhages - pathology Male Methylprednisolone Hemisuccinate - pharmacology Methylprednisolone sodium succinate Mice, Inbred C57BL Microglia - drug effects Microglia - immunology Microglia - pathology Mouse model Neurology Neurons - drug effects Neurons - immunology Neurons - pathology Neuroprotective Agents - pharmacology Neutrophils - drug effects Neutrophils - immunology Neutrophils - pathology Oedema Random Allocation
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Beschreibung
Zusammenfassung:	Highlights • MPSS treatment after ICH reduces BBB disruption and brain oedema. • MPSS also inhibits production of inflammatory cytokines and inflammation in the brain. • MPSS reduces apoptosis in the brain, perhaps by decreasing Bax and increasing Bcl-2. • This suggests that MPSS may be a useful treatment for ICH and result in improved patient prognosis.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2016.10.007