Serial Changes in Cognitive Function Following Transcatheter Aortic Valve Replacement

Abstract Background Data regarding the mid- to long-term cognitive trajectory of transcatheter aortic valve (TAVR) recipients are scarce. Objectives Changes in global cognition and specific cognitive domains up to 1 year post-TAVR were evaluated. Methods Fifty-one patients (median age 80.0 [interqua...

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Veröffentlicht in:	Journal of the American College of Cardiology 2016-11, Vol.68 (20), p.2129-2141
Hauptverfasser:	Auffret, Vincent, MD, MSc, Campelo-Parada, Francisco, MD, Regueiro, Ander, MD, Del Trigo, María, MD, Chiche, Olivier, MD, Chamandi, Chekrallah, MD, Allende, Ricardo, MD, Cordoba-Soriano, Juan G., MD, Paradis, Jean-Michel, MD, De Larochellière, Robert, MD, Doyle, Daniel, MD, Dumont, Eric, MD, Mohammadi, Siamak, MD, Côté, Mélanie, MSc, Marrero, Alier, MD, Puri, Rishi, MBBS, PhD, Rodés-Cabau, Josep, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over aortic stenosis Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - surgery Cardiology Cardiovascular cerebral embolization cognition Cognition & reasoning Cognition - physiology Cognitive ability Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology dementia Female Follow-Up Studies Humans Internal Medicine Male Memory Mortality NMR Nuclear magnetic resonance Patients Population Postoperative Complications Prognosis Prospective Studies Risk Factors Severity of Illness Index Statistical analysis Stroke Studies Time Factors Transcatheter Aortic Valve Replacement - adverse effects Variables
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Zusammenfassung:	Abstract Background Data regarding the mid- to long-term cognitive trajectory of transcatheter aortic valve (TAVR) recipients are scarce. Objectives Changes in global cognition and specific cognitive domains up to 1 year post-TAVR were evaluated. Methods Fifty-one patients (median age 80.0 [interquartile range: 72.0 to 85.0] years; 37% women) underwent TAVR and prospective assessment of cognitive function using the Montreal Cognitive Assessment (MoCA) at baseline, short-term (30 days), and 1 year post-TAVR. Processing speed and executive cognitive functions were further evaluated with the digit-symbol substitution test (DSST), Trail Making Tests (TMT), and verbal fluency tests at the same time points. Cognitive decline (CD) was determined by changes in mean scores and as a rate using practice-corrected reliable change index (RCI). Results The baseline mean total MoCA score was 22.71 ± 3.84. Twenty patients (39.2%) were considered cognitively impaired using a cutoff of
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2016.08.046