Serum protein profiling in diffuse large B-cell lymphoma

Purpose The aim of this pilot study was to conduct a nontargeted exploratory proteomics profiling analysis on sera obtained from patients diagnosed with diffuse large B‐cell lymphoma (DLBCL) with the goal of identifying disease‐specific biomarkers. Experimental design Sera from 87 participants (57 c...

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Veröffentlicht in:	Proteomics. Clinical applications 2016-11, Vol.10 (11), p.1113-1121
Hauptverfasser:	Riby, Jacques, Mobley, James, Zhang, Jianqing, Bracci, Paige M., Skibola, Christine F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - metabolism Aged Aged, 80 and over Biomarker Blood Proteins - metabolism Case-Control Studies Chromatography, High Pressure Liquid DLBCL Enzyme-Linked Immunosorbent Assay Extracellular Matrix Proteins - metabolism Heparan Sulfate Proteoglycans - metabolism Humans LCMS Lipopolysaccharide Receptors - metabolism Lymphoma, Large B-Cell, Diffuse - blood Lymphoma, Large B-Cell, Diffuse - pathology Mass Spectrometry Middle Aged NHL Peptides - analysis Pilot Projects Serum proteomics
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Zusammenfassung:	Purpose The aim of this pilot study was to conduct a nontargeted exploratory proteomics profiling analysis on sera obtained from patients diagnosed with diffuse large B‐cell lymphoma (DLBCL) with the goal of identifying disease‐specific biomarkers. Experimental design Sera from 87 participants (57 chemotherapy‐naïve diffuse DLBCL patients, 30 controls frequency‐matched by age group and World Health Organization (WHO) BMI categories) that were part of a large San Francisco Bay Area case‐control study of non‐Hodgkin lymphoma were analyzed by liquid chromatography combined with tandem mass spectrometry. Results Thirty‐five proteins (p‐adjusted
ISSN:	1862-8346 1862-8354
DOI:	10.1002/prca.201600074