Predictive cytokine biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis

Abstract A prospective study of 62 patients with relapsing-remitting multiple sclerosis (RRMS) treated with Glatiramer acetate (GA) was conducted to evaluate the value of baseline and treatment-modulated cytokines in predicting the clinical response to the drug after 2 years of therapy. There were 3...

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Veröffentlicht in:Journal of neuroimmunology 2016-11, Vol.300, p.59-65
Hauptverfasser: Valenzuela, R.M, Kaufman, M, Balashov, K.E, Ito, K, Buyske, S, Dhib-Jalbut, S
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Sprache:eng
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Zusammenfassung:Abstract A prospective study of 62 patients with relapsing-remitting multiple sclerosis (RRMS) treated with Glatiramer acetate (GA) was conducted to evaluate the value of baseline and treatment-modulated cytokines in predicting the clinical response to the drug after 2 years of therapy. There were 32 responders and 30 non-responders. GA upregulated Th2/regulatory cytokines and inhibited Th1 cytokines in sera or PBMC supernatants 3 and 6 months into treatment. We found two prognostic models with clinical utility. A model based on IL-18 at baseline, the change in TNFa from baseline to 3 months, the change in IL-4 from baseline to 6 months, and the change in the log of the ratio of TNFa/IL-4 from baseline to 6 months had an area under the curve (AUC) of 0.80. A high IL-18 level at baseline and a reduction of TNF-alpha over time are associated with a response to GA. Although the study identified predictive biomarkers of clinical response to GA, the results will need to be validated in other data sets.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2016.06.005