Modulatory effects of an NMDAR partial agonist in MK-801-induced memory impairment

Highlights • Neurobehavioral deficits induced by MK-801 were inhibited by DCS. • DCS counteracted MK-801 induced increase in dopamine level, AChE & MAO activity. • DCS controlled the degree of overexpression of c-fos induced by MK-801. • Improving NMDAR function by DCS may play vital role in neu...

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Veröffentlicht in:	Neuroscience 2015-12, Vol.311, p.22-33
Hauptverfasser:	Vishnoi, S, Raisuddin, S, Parvez, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Avoidance Learning - drug effects Avoidance Learning - physiology Behavior c-fos Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Cycloserine - pharmacology d-cycloserine Disease Models, Animal Dizocilpine Maleate Dopamine Dopamine - metabolism Exploratory Behavior - drug effects Exploratory Behavior - physiology Female Memory Disorders - drug therapy Memory Disorders - metabolism MK-801 Monoamine Oxidase - metabolism Neurology NMDAR Nootropic Agents - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Proto-Oncogene Proteins c-fos - metabolism Rats, Wistar Receptors, N-Methyl-D-Aspartate - agonists Receptors, N-Methyl-D-Aspartate - metabolism Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Taste Perception - drug effects Taste Perception - physiology
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Zusammenfassung:	Highlights • Neurobehavioral deficits induced by MK-801 were inhibited by DCS. • DCS counteracted MK-801 induced increase in dopamine level, AChE & MAO activity. • DCS controlled the degree of overexpression of c-fos induced by MK-801. • Improving NMDAR function by DCS may play vital role in neuropsychiatric disorders.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.10.008