Chronic social defeat stress increases dopamine D2 receptor dimerization in the prefrontal cortex of adult mice

Highlights • Increased D2S in PFC of susceptible mice compared to controls. • Increased D2L in the PFC of susceptible mice compared with controls. • Increased D2Rs dimers in PFC of susceptible mice compared with controls.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-12, Vol.311, p.444-452
Hauptverfasser:	Bagalkot, T.R, Jin, H.-M, Prabhu, V.V, Muna, S.S, Cui, Y, Yadav, B.K, Chae, H.-J, Chung, Y.-C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - metabolism Animals Blotting, Western Carrier Proteins - metabolism Chronic Disease Corpus Striatum - metabolism Dimerization Disease Models, Animal Dominance-Subordination dopamine D2 receptor dimers dopamine receptor isoforms G protein-coupled receptor-associated sorting protein-1 Hippocampus - metabolism Mice, Inbred C57BL Neurology neuronal calcium sensor-1 Neuronal Calcium-Sensor Proteins - metabolism Neuropeptides - metabolism Polymerase Chain Reaction Prefrontal Cortex - metabolism Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Resilience, Psychological RNA, Messenger - metabolism social defeat Stress, Psychological - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Increased D2S in PFC of susceptible mice compared to controls. • Increased D2L in the PFC of susceptible mice compared with controls. • Increased D2Rs dimers in PFC of susceptible mice compared with controls.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.10.024