Activation of inositol 1,4,5-trisphosphate receptors during preconditioning low-frequency stimulation suppresses subsequent induction of long-term potentiation in hippocampal CA1 neurons

Highlights • A train of LFS given prior to the delivery of HFS suppresses LTP induction in hippocampal CA1 neurons. • Co-activation of IP3 receptors and NMDA receptors during LFS results in both phosphorylation and dephosphorylation events. • Both of these events lead to prolonged activation of grou...

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Veröffentlicht in:	Neuroscience 2015-12, Vol.311, p.195-206
Hauptverfasser:	Yamazaki, Y, Fujii, S, Goto, J.-I, Fujiwara, H, Mikoshiba, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiology CA1 synapses calcineurin Calcium - metabolism Electric Stimulation - methods Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Guinea Pigs Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors Inositol 1,4,5-Trisphosphate Receptors - metabolism IP3 receptors Long-Term Potentiation - drug effects Long-Term Potentiation - physiology LTP LTP suppression Male Neurology Neurotransmitter Agents - pharmacology preconditioning Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Synapses - drug effects Synapses - physiology Tissue Culture Techniques
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Zusammenfassung:	Highlights • A train of LFS given prior to the delivery of HFS suppresses LTP induction in hippocampal CA1 neurons. • Co-activation of IP3 receptors and NMDA receptors during LFS results in both phosphorylation and dephosphorylation events. • Both of these events lead to prolonged activation of group I mGluRs that is responsible for the LTP suppression. • These results help us understand how activation of IP3 receptors contributes to the regulation of learning modes.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.10.030