Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone

Highlights • Baicalin prevents depressive-like behaviors induced by CORT. • Baicalin reverses the increased mRNA and protein expression of SGK1 in the hippocampus induced by CORT. • Baicalin increases the hippocampal protein expression of 11β-HSD2, GRα and BDNF in CORT-treated mice.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-12, Vol.311, p.130-137
Hauptverfasser:	Li, Y.-C, Wang, L.-L, Pei, Y.-Y, Shen, J.-D, Li, H.-B, Wang, B.-Y, Bai, M
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism Animals Antidepressive Agents - pharmacology baicalin brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Corticosterone cortiscosterone depression Depressive Disorder - drug therapy Depressive Disorder - metabolism Dietary Sucrose Disease Models, Animal Dose-Response Relationship, Drug Feeding Behavior - drug effects Feeding Behavior - physiology Flavonoids - pharmacology Hippocampus - drug effects Hippocampus - metabolism Immediate-Early Proteins - metabolism Motor Activity - drug effects Motor Activity - physiology Neurology Protein-Serine-Threonine Kinases - metabolism Random Allocation Receptors, Glucocorticoid - metabolism RNA, Messenger - metabolism serum- and glucocorticoid-regulated kinase 1 Swimming Taste Perception - drug effects Taste Perception - physiology
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Beschreibung
Zusammenfassung:	Highlights • Baicalin prevents depressive-like behaviors induced by CORT. • Baicalin reverses the increased mRNA and protein expression of SGK1 in the hippocampus induced by CORT. • Baicalin increases the hippocampal protein expression of 11β-HSD2, GRα and BDNF in CORT-treated mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.10.023