Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task

Highlights • Post-training infusion of bicuculline did not alter but muscimol impaired memory. • I.p. injection of harmane impaired memory consolidation. • Bicuculline decreased, but muscimol increased amnesia induced by harmane. • There is an additive effect among harmane and muscimol on impairment...

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Veröffentlicht in:	Neuroscience 2016-12, Vol.339, p.287-295
Hauptverfasser:	Nasehi, Mohammad, Morteza-zadeh, Parastu, Khakpai, Fatemeh, Zarrindast, Mohammad-Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avoidance Learning - drug effects Avoidance Learning - physiology CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - pathology Dose-Response Relationship, Drug GABA-A Receptor Agonists - pharmacology GABA-A Receptor Antagonists - pharmacology GABAA receptor harmane Harmine - analogs & derivatives Harmine - pharmacology Male memory Memory Consolidation - drug effects Memory Consolidation - physiology Memory Disorders - drug therapy Memory Disorders - metabolism Memory Disorders - pathology Mice Motor Activity - drug effects Motor Activity - physiology Muscimol - pharmacology Neurology Nootropic Agents - pharmacology Receptors, GABA-A - metabolism step-down passive avoidance the CA1 area
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Zusammenfassung:	Highlights • Post-training infusion of bicuculline did not alter but muscimol impaired memory. • I.p. injection of harmane impaired memory consolidation. • Bicuculline decreased, but muscimol increased amnesia induced by harmane. • There is an additive effect among harmane and muscimol on impairment of memory. • GABAergic system of the CA1 may modulate harmane-induced amnesia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.10.007