HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels

Background High-density lipoproteins (HDLs) protect against the development of atherosclerotic cardiovascular disease. HDL function represents an emerging concept in cardiovascular research. Objective This study investigated the association between HDL functionality and acute myocardial infarction (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical lipidology 2016-11, Vol.10 (6), p.1318-1328
Hauptverfasser:	Annema, Wijtske, PhD, Willemsen, Hendrik M., MD, de Boer, Jan Freark, PhD, Dikkers, Arne, MSc, van der Giet, Markus, MD, Nieuwland, Wybe, MD, Muller Kobold, Anneke C., PhD, van Pelt, L. Joost, MD, PhD, Slart, Riemer H.J.A., MD, PhD, van der Horst, Iwan C.C., MD, PhD, Dullaart, Robin P.F., MD, PhD, Tio, René A., MD, PhD, Tietge, Uwe J.F., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndrome Acute Disease Adult Aged Amine Oxidase (Copper-Containing) - metabolism C-Reactive Protein - analysis Cardiovascular Cell Adhesion Molecules - metabolism Cholesterol Cholesterol efflux Cholesterol, HDL - blood Creatine Kinase - blood Creatine Kinase, MB Form - blood Female Follow-Up Studies Gene Expression - drug effects HDL function Human Umbilical Vein Endothelial Cells Humans Inflammation Linear Models Macrophages - metabolism Male Middle Aged Myocardial Infarction - diagnosis Oxidation Prospective Studies Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background High-density lipoproteins (HDLs) protect against the development of atherosclerotic cardiovascular disease. HDL function represents an emerging concept in cardiovascular research. Objective This study investigated the association between HDL functionality and acute myocardial infarction (MI) independent of HDL-cholesterol plasma levels. Methods Participants (non-ST-segment elevation MI, non-STEMI, n = 41; STEMI, n = 37; non-MI patients, n = 33) from a prospective follow-up study enrolling patients with acute chest pain were matched for age and plasma HDL cholesterol. The in vitro capacity of HDL to (1) mediate cholesterol efflux from macrophage foam cells, (2) prevent low-density lipoprotein oxidation, and (3) inhibit TNF-α-induced vascular adhesion molecule-1 expression in endothelial cells was determined. Results STEMI-HDL displayed reduced cholesterol efflux ( P
ISSN:	1933-2874 1876-4789
DOI:	10.1016/j.jacl.2016.08.003