LGN Input to Simple Cells and Contrast-Invariant Orientation Tuning: An Analysis

1 Department of Psychology, Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742; 2 National Aeronautics and Space Administration Ames Research Center, Moffett Field 94035-1000; and 3 Departments of Physiology and Otolaryngology, W. M. Keck Center for Integrative Neuroscience, Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, California 94143-0444 Troyer, Todd W., Anton E. Krukowski, and Kenneth D. Miller. LGN Input to Simple Cells and Contrast-Invariant Orientation Tuning: An Analysis. J. Neurophysiol. 87: 2741-2752, 2002. We develop a new analysis of the lateral geniculate nucleus (LGN) input to a cortical simple cell, demonstrating that this input is the sum of two terms, a linear term and a nonlinear term. In response to a drifting grating, the linear term represents the temporal modulation of input, and the nonlinear term represents the mean input. The nonlinear term, which grows with stimulus contrast, has been neglected in many previous models of simple cell response. We then analyze two scenarios by which contrast-invariance of orientation tuning may arise. In the first scenario, at larger contrasts, the nonlinear part of the LGN input, in combination with strong push-pull inhibition, counteracts the nonlinear effects of cortical spike threshold, giving the result that orientation tuning scales with contrast. In the second scenario, at low contrasts, the nonlinear component of LGN input is negligible, and noise smooths the nonlinearity of spike threshold so that the input-output function approximates a power-law function. These scenarios can be combined to yield contrast-invariant tuning over the full range of stimulus contrast. The model clarifies the contribution of LGN nonlinearities to the orientation tuning of simple cells and demonstrates how these nonlinearities may impact different models of contrast-invariant tuning.