Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer

Highlights • Recently tumor biologists and chemists have focused on polymeric and biodegradable nanoparticles such as chitosan. • In the present study we designed and synthesized a chitosan based nanoparticles, ChNPs, to deliver doxorubicin (DOX), and Snail siRNA to HCT-116 colorectal cancer cells....

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Veröffentlicht in:	Immunology letters 2017-01, Vol.181, p.79-86
Hauptverfasser:	Sadreddini, Sanam, Safaralizadeh, Reza, Baradaran, Behzad, Aghebati-Maleki, Leili, Hosseinpour-Feizi, Mohammad Ali, Shanehbandi, Dariush, Jadidi-Niaragh, Farhad, Sadreddini, Sevil, Kafil, Hossein Samadi, Younesi, Vahid, Yousefi, Mehdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antineoplastic Agents - administration & dosage Biomarkers Cell Line, Tumor Cell Proliferation Chitosan Chitosan nanoparticle Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Disease Models, Animal Doxorubicin Drug Delivery Systems Gene Expression Regulation, Neoplastic Gene Transfer Techniques Humans Mice Nanoparticles RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics siRNA Snail Spectroscopy, Fourier Transform Infrared Wound Healing - drug effects Wound Healing - genetics Xenograft Model Antitumor Assays
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Beschreibung
Zusammenfassung:	Highlights • Recently tumor biologists and chemists have focused on polymeric and biodegradable nanoparticles such as chitosan. • In the present study we designed and synthesized a chitosan based nanoparticles, ChNPs, to deliver doxorubicin (DOX), and Snail siRNA to HCT-116 colorectal cancer cells. • Our findings confirmed that using dual delivery of DOX and Snail siRNA using ChNPs inhibited growth, proliferation and migration of HCT-116 cells.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.11.013