Validation of the prognostic role of the “Helsinki Score” in 225 cases of adrenocortical carcinoma

Adrenocortical carcinoma patient prognosis is extremely variable and poorly predictable. The newly introduced Helsinki Score is the first so far proposed diagnostic and prognostic system based on the combined evaluation of morphological (mitoses and necrosis) and immunohistochemical (Ki-67) paramete...

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Veröffentlicht in:	Human pathology 2017-04, Vol.62, p.1-7
Hauptverfasser:	Duregon, Eleonora, Cappellesso, Rocco, Maffeis, Valeria, Zaggia, Barbara, Ventura, Laura, Berruti, Alfredo, Terzolo, Massimo, Fassina, Ambrogio, Volante, Marco, Papotti, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Cortex Neoplasms - chemistry Adrenal Cortex Neoplasms - classification Adrenal Cortex Neoplasms - mortality Adrenal Cortex Neoplasms - pathology Adrenocortical carcinoma Adrenocortical Carcinoma - chemistry Adrenocortical Carcinoma - classification Adrenocortical Carcinoma - mortality Adrenocortical Carcinoma - pathology Adult Aged Algorithms Area Under Curve Child Child, Preschool Classification Colleges & universities Decision Support Techniques Female Gangrene Gene expression Helsinki Score Histopathology Humans Immunohistochemistry Infant Italy Kaplan-Meier Estimate Ki-67 Ki-67 Antigen - analysis Male Medical prognosis Metastasis Middle Aged Mitosis Mitotic count Morphology Multivariate analysis Necrosis Neuroendocrine tumors Pathology Pediatrics Predictive Value of Tests Prognosis Proportional Hazards Models Reproducibility of Results ROC Curve Survival analysis Tumors Young Adult
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Zusammenfassung:	Adrenocortical carcinoma patient prognosis is extremely variable and poorly predictable. The newly introduced Helsinki Score is the first so far proposed diagnostic and prognostic system based on the combined evaluation of morphological (mitoses and necrosis) and immunohistochemical (Ki-67) parameters. The aim of the study was to validate the prognostic role of the Helsinki Score for adrenocortical carcinoma characterization. Thus, 225 adrenocortical carcinomas were reclassified using the Weiss Score and the Helsinki Score (3× mitotic count +5× necrosis + Ki-67 index). At univariate analysis, statistically significant prognostic values were observed at the log-rank test for mitotic count (cut-off values:
ISSN:	0046-8177 1532-8392
DOI:	10.1016/j.humpath.2016.09.035