Associations between the CNTNAP2 gene, dorsolateral prefrontal cortex, and cognitive performance on the Stroop task

Associations between the CNTNAP2 gene, dorsolateral prefrontal cortex, and cognitive performance on the Stroop task

Highlights • The CNTNAP2 genetic variations were associated with DLPFC volume and surface area. • Subjects with greater left DLPFC surface area had better cognitive performance. • Left DLPFC surface area mediated the association between CNTNAP2 and cognition.

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Veröffentlicht in:Neuroscience 2017-02, Vol.343, p.21-29
Hauptverfasser: Zhu, Bi, Chen, Chuansheng, Xue, Gui, Lei, Xuemei, Wang, Yunxin, Li, Jin, Moyzis, Robert K, Li, Jun, Dong, Qi, Lin, Chongde
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Analysis of Variance
Asian Continental Ancestry Group - genetics
Asian Continental Ancestry Group - psychology
China
Cognition
dorsolateral prefrontal cortex
Executive Function
Female
Functional Laterality
gene
Genotyping Techniques
Haplotypes
Humans
imaging genetics
Magnetic Resonance Imaging
Male
Membrane Proteins - genetics
MRI
Nerve Tissue Proteins - genetics
Neurology
Organ Size
Polymorphism, Single Nucleotide
Prefrontal Cortex - diagnostic imaging
Reaction Time
Stroop
Stroop Test
Young Adult
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Zusammenfassung:Highlights • The CNTNAP2 genetic variations were associated with DLPFC volume and surface area. • Subjects with greater left DLPFC surface area had better cognitive performance. • Left DLPFC surface area mediated the association between CNTNAP2 and cognition.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.11.021